PT  - JOURNAL ARTICLE
AU  - Kister, Sven J.
TI  - CARBONIC ANHYDRASE INHIBITION. VI. THE EFFECT OF ACETAZOLAMIDE ON CEREBROSPINAL FLUID FLOW
DP  - 1956 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 402--405
VI  - 117
IP  - 4
4099  - http://jpet.aspetjournals.org/content/117/4/402.short
4100  - http://jpet.aspetjournals.org/content/117/4/402.full
SO  - J Pharmacol Exp Ther1956 Aug 01; 117
AB  - We confirm the work of Tschirgi et al. (1954), showing that acetazolamide reduces CSF flow rate in the cat. There appear to be at least three characteristics of this response. The flow rate declines to approximately 30 per cent of control rates, and appears independent of dose of acetazolamide in the range of 0.5 to 150 mgm./kgm. The onset of the effect occurs within 5 minutes, reaches a maximum within 30 minutes, and persists for several hours following acetazolamide at 1 to 150 mgm./kgm. Work with CL 8490 and CL 13850 shows that compounds closely resembling acetazolamide chemically, but without action against carbonic anhydrase, have no effect on CSF flow. The decline in CSF flow following acetazolamide thus appears due to its effect on inhibition of this enzyme. No effect of acetazolamide apart from its action on carbonic anhydrase has been reported.