RT Journal Article
SR Electronic
T1 METABOLISM OF THE ULTRASHORT-ACTING THIOBARBITURATE, METHITURAL (NERAVAL)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 287
OP 297
VO 117
IS 3
A1 Blake, Margaret W.
A1 Perlman, Preston L.
YR 1956
UL http://jpet.aspetjournals.org/content/117/3/287.abstract
AB The metabolism of methitural and thiopental was compared in the dog and the rat. Methitural like thiopental was rapidly absorbed into the body fat depots. Countercurrent distribution studies showed that the substance present in fat was actually methitural and that no unchanged methitural was excreted in the urine. Methitural was degraded by the liver and was eliminated from the rat carcass more rapidly than was thiopental. The rapid absorption into fat and the degradation by the liver account for the short duration of and rapid recovery from methitural anesthesia.