RT Journal Article
SR Electronic
T1 EFFECTS OF RESERPINE ON CONDITIONED AVOIDANCE BEHAVIOR IN NORMAL AND BRAIN-OPERATED MONKEYS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 136
OP 141
VO 117
IS 2
A1 Smith, Richard P.
A1 Wagman, Althea I.
A1 Riopelle, Arthur J.
YR 1956
UL http://jpet.aspetjournals.org/content/117/2/136.abstract
AB Three groups of brain-operated rhesus monkeys, differing as to size and location of lesion, and a group of nonoperated control monkeys, were trained to jump over a barrier in a shuttle-box to avoid shock. After extensive training the animals were injected with 0.15, 0.25 and 0.37 mgm./kgm. of reserpine. At least four days intervened between successive injections. Performance was tested 1, 2, 4, 6, and 10 hours after injection. Results gathered by the present techniques revealed clear cut time-response curves which differed from dose level to dose level and from group to group. Greatest decrement in performance was shown at 4 and 6 hours after injection, with complete recovery occurring after 10 hours. Nonoperated animals were affected more severely than were the operated animals. Animals with lesions in the temporal lobes showed greater sparing than animals with frontal lesions.