RT Journal Article
SR Electronic
T1 THE EFFECT OF HYDROCORTISONE ON THE OXYGEN UPTAKE OF INFLAMED TISSUE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 51
OP 53
VO 114
IS 1
A1 Harold C. Heim
A1 Richard A. Deitrich
A1 John G. McDonald
YR 1955
UL http://jpet.aspetjournals.org/content/114/1/51.abstract
AB Inflammation was induced in rats by the injection of croton oil, and the Qo2, of the inflamed tissue was determined. The addition of adenylate to the homogenates was found to increase the Qo2, The Qo2 was found to be increased after the injection of hydrocortisone into the granuloma pouches but this effect was not observed when the hydrocortisone was replaced by either desoxycorticosterone, progesterone, or cholesterol. The effects observed with hydrocortisone were not observed in vitro, but rather were observed only with homogenates prepared from the tissue from animals previously injected with hydrocortisone.