RT Journal Article
SR Electronic
T1 THE ACTION OF MERCURIAL DIURETICS ON URINARY SODIUM CONCENTRATION AND URINE VOLUME
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 256
OP 261
VO 113
IS 3
A1 A. FARAH
A1 F. KODA
YR 1955
UL http://jpet.aspetjournals.org/content/113/3/256.abstract
AB An attempt was made to separate the effects of the mercurial diuretic mersalyl on urine volume and urinary sodium concentration. By using small graded doses of mersalyl it was possible to increase the urinary sodium concentration without affecting urine volume. This effect of the mercurial could be reversed with 2,3 dimercaptopropanol. A large dose of the mercurial produced both urinary sodium concentration and urine volume changes. By injecting small doses of BAL it was possible to reverse the mercurial induced volume change with no decrease in the mercurial induced sodium concentration changes. An increase in the dosage of BAL also reversed these concentration changes. In the light of these experiments it is postulated that mercurials act on renal sodium concentration controlling mechanisms and on urine volume. © 1955, by The Williams & Wilkins Company