PT  - JOURNAL ARTICLE
AU  - Carl C. Gruhzit
AU  - W. A. Freyburger
AU  - G. K. Moe
TI  - THE ACTION OF VERILOID ON CAROTID PRESSORECEPTORS
DP  - 1953 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 261--267
VI  - 109
IP  - 3
4099  - http://jpet.aspetjournals.org/content/109/3/261.short
4100  - http://jpet.aspetjournals.org/content/109/3/261.full
SO  - J Pharmacol Exp Ther1953 Nov 01; 109
AB  - The depressor action of Veriloid in dogs was abolished by section of the vagi and of the carotid sinus nerves, but not by either procedure alone. Following vagotomy, denervation of the carotid pressoreceptors without destruction of the chemoreceptors completely prevented the depressor response to the drug. Since Veriloid did not potentiate the depressor effect of submaximal electrical stimulation of the carotid nerves, it was concluded that the drug causes hypotension by sensitization of the stretch receptors, rather than by facilitation of central components of the reflex arc.