TY - JOUR T1 - THE METABOLISM AND CONTRACTION OF CAT HEART MUSCLES AS AFFECTED BY DRUGS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 484 LP - 494 VL - 112 IS - 4 AU - Kwang Soo Lee Y1 - 1954/12/01 UR - http://jpet.aspetjournals.org/content/112/4/484.abstract N2 - The oxygen consumption of papillary muscles increased following activity and this increase was proportional to the rate of stimulation with frequencies up to sixty per minute. Iodoacetate and fluoroacetate appear to inhibit the contraction of the muscle by interfering with the metabolism of the muscle thus decreasing the energy available for contraction. The lack of energy available following the impairment of the metabolic pathways in poisoned muscles is manifested in the staircase phenomenon of the muscles. Dinitrophenol increases oxygen consumption while decreasing the contractility of the muscle. ER -