RT Journal Article
SR Electronic
T1 THE ACTION OF ACETYLCHOLINE AND ESERINE ON SPONTANEOUS MUSCULAR MOVEMENT IN FISH EMBRYOS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 257
OP 260
VO 112
IS 2
A1 Floyd J. Brinley
YR 1954
UL http://jpet.aspetjournals.org/content/112/2/257.abstract
AB Experiments on fish embryos, Aequedens partalegrensis and Oryzias latipes demonstrated that: 1. Acetylcholine and eserine have no significant effect on the muscular activity of uninnervated somatic muscles. 2. The action of both drugs on the innervated muscles results in an initial stimulation, followed by tetany and finally a refractory period. 3. The place of action of acetylcholine appears to be on the motor end plate. 4. There seems to be no significant difference between the effect of exogenous acetylcholine and endogenous acetylcholine which is allowed to accumulate by inactivation of the cholinesterase with eserine.