PT  - JOURNAL ARTICLE
AU  - Julius Axelrod
AU  - Sidney Udenfriend
AU  - Bernard B. Brodie
TI  - ASCORBIC ACID IN AROMATIC HYDROXYLATION. III. EFFECT OF ASCORBIC ACID ON HYDROXYLATION OF ACETANILIDE, ANILINE AND ANTIPYRINE <em>IN VIVO</em>
DP  - 1954 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 176--181
VI  - 111
IP  - 2
4099  - http://jpet.aspetjournals.org/content/111/2/176.short
4100  - http://jpet.aspetjournals.org/content/111/2/176.full
SO  - J Pharmacol Exp Ther1954 Jun 01; 111
AB  - The rate of hydroxylation of acetanilide, aniline and antipyrine is markedly reduced in guinea pigs depleted of ascorbic acid. On repletion of the animals with ascorbic acid the rate of hydroxylation is restored to normal. The possible role of ascorbic acid in the hydroxylation of drugs of aromatic character is discussed.