RT Journal Article
SR Electronic
T1 THE INFLUENCE OF PLASMA ELECTROLYTE CONCENTRATION ON MERCURIAL DIURESIS IN THE DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 361
OP 368
VO 110
IS 3
A1 A. Farah
A1 F. Koda
YR 1954
UL http://jpet.aspetjournals.org/content/110/3/361.abstract
AB It has been shown that the mercurial induced natriuresis and chloruresis are related to the plasma sodium concentration and to the degree of positive fluid balance. Plasma sodium and chloride concentrations determined the mercurial induced increase in the urinary electrolyte concentration while the fluid balance could be related to the mercurial induced urinary volume change. By lowering plasma sodium concentration to about 80-90 mM per liter the animals became refractory to mersalyl but still responded to an injection of a toxic dose of cyanide. On the basis of these experiments two distinct sodium reabsorptive processes have been postulated: a) a mercury-sensitive one and b) a mercury-insensitive but cyanide-sensitive one.