RT Journal Article
SR Electronic
T1 ANTAGONISM OF THREE HOMOLOGOUS MONOFLUORINATED FATTY ACIDS BY SEVERAL FATTY ACIDS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 344
OP 351
VO 110
IS 3
A1 Leland C. Hendershot
A1 Maynard B. Chenoweth
YR 1954
UL http://jpet.aspetjournals.org/content/110/3/344.abstract
AB 1. In the presence of either acetate, butyrate, or hexanoate as substrates, fluoroacetate, fluorobutyrate, and fluorohexanoate all inhibit the isolated rabbit intestinal strip; but the various substrates antagonize the fluoroacids to different degrees. 2. Fluoroacetate is best antagonized by acetate; fluorobutyrate and fluorohexanoate are best antagonized by hexanoate. 3. The effects of the fluoro fatty acids upon fatty acid metabolism and its possible significance in fluoroacid poisoning is discussed in the light of specific fatty acid enzyme systems.