RT Journal Article
SR Electronic
T1 THE EVALUATION OF SOME N-SUBSTITUTED ARTERENOL DERIVATIVES AS BRONCHODILATORS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 304
OP 308
VO 110
IS 3
A1 R. A. Seibert
A1 Carroll A. Handley
YR 1954
UL http://jpet.aspetjournals.org/content/110/3/304.abstract
AB A modified method has been developed to determine the relative activity of compounds as bronchodilators in the anesthetized dog. The method utilizes an infant respirator (Iron Lung) to maintain a constant respiratory pressure in curarized dogs. By slow infusion of the curare-like drug, voluntary respiration can be abolished without producing bronchoconstriction or a lowering of the blood pressure. A series of compounds has been tested, all of which are N-substituted arterenol derivatives. The most active compound JB-245 (N-2-(1-(4-methoxyphenyl)-propyl)arterenol) has approximately the same activity as Isuprel as a bronchodilator.