PT  - JOURNAL ARTICLE
AU  - R. A. Seibert
AU  - Carroll A. Handley
TI  - THE EVALUATION OF SOME N-SUBSTITUTED ARTERENOL DERIVATIVES AS BRONCHODILATORS
DP  - 1954 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 304--308
VI  - 110
IP  - 3
4099  - http://jpet.aspetjournals.org/content/110/3/304.short
4100  - http://jpet.aspetjournals.org/content/110/3/304.full
SO  - J Pharmacol Exp Ther1954 Mar 01; 110
AB  - A modified method has been developed to determine the relative activity of compounds as bronchodilators in the anesthetized dog. The method utilizes an infant respirator (Iron Lung) to maintain a constant respiratory pressure in curarized dogs. By slow infusion of the curare-like drug, voluntary respiration can be abolished without producing bronchoconstriction or a lowering of the blood pressure. A series of compounds has been tested, all of which are N-substituted arterenol derivatives. The most active compound JB-245 (N-2-(1-(4-methoxyphenyl)-propyl)arterenol) has approximately the same activity as Isuprel as a bronchodilator.