RT Journal Article
SR Electronic
T1 THE ANTI-EMETIC ACTIVITY OF 10-(γ-DIMETHYLAMINOPROPYL)-2-CHLOROPHENOTHIAZINE (CHLORPROMAZINE) IN DOG AND CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 86
OP 92
VO 110
IS 1
A1 E. D. Brand
A1 T. D. Harris
A1 H. L. Borison
A1 L. S. Goodman
YR 1954
UL http://jpet.aspetjournals.org/content/110/1/86.abstract
AB Chlorpromazine, 10-(γ-dimethylaminopropyl)-2-chlorophenothiazine hydro-chloride, a non-antihistaminic congener of Phenergan, was tested for its efficacy against apomorphine-induced emesis in 6 standardized dogs; the drug was also tested against morphine, ergot (Hydergine), intravenous and oral copper sulfate, lanatoside-C and veratrum (Veriloid). In cats, Chlorpromazine was examined for its ability to prevent vomiting caused by apomorphine, lanatoside-C, veratrum, nitrogen mustard, pilocarpine and intravenous copper sulfate. In dogs, Chlorpromazine is markedly effective in antagonizing apomorphine-induced emesis, whereas Phenergan showed no protective effect. Chlorpromazine also protects against vomiting evoked by morphine and ergot, but it is ineffective against intravenous copper sulfate, lanatoside-C, veratrum and oral copper sulfate. The pattern of anti-emetic action of Chlorpromazine in dogs suggests that the mechanism of its action is a selective depression of the medullary emetic chemoreceptor trigger zone. In cats, Chlorpromazine did not prevent vomiting induced by apomorphine, lanatoside-C and intravenous copper sulfate. Attention is called to the anatomic and pharmacologic differences in the emetic chemoreceptor trigger zone of cats and dogs. The possible relation between the clinical anti-emetic usefulness of Chlorpromazine and its efficacy in laboratory animals is briefly discussed. 1954 by The American Society for Pharmacology and Experimental Therapeutics