RT Journal Article SR Electronic T1 A PHARMACOLOGICAL COMPARISON OF THE OPTICAL ISOMERS OF 5-ETHYL-5-PHENYL HYDANTOIN (NIRVANOL) AND OF 3-METHYL-5-ETHYL-PHENYL HYDANTOIN (MESANTOIN) JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 120 OP 125 VO 110 IS 1 A1 Thomas C. Butler A1 William J. Waddell YR 1954 UL http://jpet.aspetjournals.org/content/110/1/120.abstract AB The levorotatory isomers of 5-ethyl-5-phenyl hydantoin (Nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin) are more active as anesthetics in mice than are their respective antipodes. l-Nirvanol anesthetizes mice in lower dosage than does the corresponding Mesantoin isomer. d-Kirvanol disappears from the plasma of the rat much more rapidly than does l- and produces a briefer anesthesia in mice than does l-. l-Mesantoin is demethylated by the rat at a greater rate than is its isomer. Species differences in the physiological disposition of Nirvanol and Mesantoin are discussed. 1954 by The American Society for Pharmacology and Experimental Therapeutics