RT Journal Article
SR Electronic
T1 ON THE METABOLIC FATE OF ISONIAZID
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 444
OP 452
VO 109
IS 4
A1 Hettie B. Hughes
YR 1953
UL http://jpet.aspetjournals.org/content/109/4/444.abstract
AB This report deals with studies on the excretion and metabolism of isoniazid in the rhesus monkey. These studies have demonstrated that the equivalent of from 50 to 100 per cent of orally administered isoniazid is eliminated in the urine. The major component of this excretion has been isolated and identified as 1-isonicotinyl-2-acetylhydrazine. It was found in the urine of one patient to the extent of 91 per cent of the isoniazid-like materials excreted, so it is not unlikely that this acetyl derivative is the major metabolic product in man. The significance of this finding as it relates to the toxicity and chemotherapeutic activity of isoniazid and to previous work on the metabolic fate of this drug has been discussed.