RT Journal Article
SR Electronic
T1 THE INHIBITORY EFFECTS OF COLCHICINE ON THE GASTRIC SECRETION PRODUCED BY HISTAMINE AND OTHER SECRETAGOGUES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 361
OP 365
VO 109
IS 3
A1 W. Koskowski
A1 M. Mahfouz
YR 1953
UL http://jpet.aspetjournals.org/content/109/3/361.abstract
AB The gastric secretion produced by histamine in pigeons with gastric fistulas could be greatly inhibited by the repeated administration of colchicine. The onset of secretion was delayed, the amount of juice reduced or completely arrested and its acidity greatly lowered. This inhibition was reversible and could be largely prevented by the previous administration of yeast. The degree of this inhibition was greater than that produced by the specific antihistaminic drug, Anthisan. Colchicine also produced powerful inhibitory effects on the gastric secretion produced by alcohol, whether administered intravenously or intraduodenally, and by histidine-ascorbic acid combination. At present no satisfactory explanation of the inhibitory effects of colchicine on the gastric secretion and on the hydrochloric acid formation in the oxyntic cells of the gastric mucosa can be given.