TY - JOUR T1 - DISTRIBUTION AND EXCRETION OF C<sup>14</sup> LABELED PRISCOLINE-HCl IN RATS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 318 LP - 327 VL - 109 IS - 3 AU - Bernard Century AU - L. E. Ellinwood AU - J. D. Kohli AU - J. M. Coon Y1 - 1953/11/01 UR - http://jpet.aspetjournals.org/content/109/3/318.abstract N2 - Priscoline hydrochloride labeled with C14 was found to be rapidly excreted in the urine following administration to rats. Paper chromatographic analysis was used to show that almost all of the excreted radioactive material was in the form of unchanged Priscoline. Of the various ongans, liver and kidney took up the greatest concentrations of C14 after both imitravenous and oral administration of the radioactive Priscoline The uptake of radioactivity by the brain, in contrast, was low. Absorption of the drug from the gastrointestinal tract was rapid, as was seen by analysis of the contents and by the similarity of the distribution and excretion pattern following oral and intravenous administration. Small amounts of radioactivity in the expired air, and the presence of a water soluble fraction which is not extractable by chloroform from alkaline solution constitute evidence that a small amount of the administered radioactive Priscohue is metabolized. The chief radioactive product resulting from the bm-eakdown of Priscoline by alkali is largely extractable by chloroform and does not resemble any possible metabolite obtaimied from rats. It is not known whether or not a water soluble fraction which also results is the same as that excreted by the animals. ER -