PT  - JOURNAL ARTICLE
AU  - Funderburk, W. H.
AU  - Unna, K. R.
TI  - SITE OF ACTION OF 2,2-DIETHYL 1,3-PROPANEDIOL (PRENDEROL) ON THE CENTRAL NERVOUS SYSTEM
DP  - 1953 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 344--355
VI  - 107
IP  - 3
4099  - http://jpet.aspetjournals.org/content/107/3/344.short
4100  - http://jpet.aspetjournals.org/content/107/3/344.full
SO  - J Pharmacol Exp Ther1953 Mar 01; 107
AB  - The effects of Prenderol have been studied at various levels of the cerebrospinal axis, alld compared with the effects of mephenesin. 1. The drug had a depressant action on spinal interneurons similar to that of mephenesin. 2. Its potency was approximately one-third of that of mephenesin and its duration of action was shorter. 3. The action of mephenesin on the EEG suggested depression of interneurons in the brain stem activating system and in thalamo-cortical pathways. In contrast Prenderol showed stimulating effects above the spinal level.