PT  - JOURNAL ARTICLE
AU  - Lloyd C. Felton
AU  - Harold H. Bryant
AU  - Edward H. Frieden
TI  - THE EFFECTS OF OVARIAN EXTRACTS UPON ACTIVITY OF THE GUINEA PIG UTERUS <em>IN SITU</em>
DP  - 1953 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 160--164
VI  - 107
IP  - 2
4099  - http://jpet.aspetjournals.org/content/107/2/160.short
4100  - http://jpet.aspetjournals.org/content/107/2/160.full
SO  - J Pharmacol Exp Ther1953 Feb 01; 107
AB  - Studies of the chemical properties of a uterine relaxing factor (URF), obtained from aqueous extracts of sows' ovaries indicate that the active agent is non-dialyzable, stable to heat, and sensitive to the action of proteolytic enzymes and a variety of reducing agents. It is concluded that URF is a protein or polypeptide. URF activity is also displayed by both crude and purified relaxin preparations, and comparison of the occurrence of URF and relaxin in various tissues suggests a close relationship between the two substances. The possible relationship of protein-like hormones of the reproductive tract to changes in uterine motility have been discussed.