TY - JOUR T1 - A STUDY OF THE METABOLISM OF Cl4 SALICYLAMIDE IN THE HUMAN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 433 LP - 439 VL - 106 IS - 4 AU - H. George Mandel AU - Paul K. Smith AU - Victor W. Rodwell Y1 - 1952/12/01 UR - http://jpet.aspetjournals.org/content/106/4/433.abstract N2 - Salicylamide-C14 has been prepared in this laboratory from C14 salicylic acid. The major urinary metabolite after the oral administration of 300 mgm. of the drug to cancer patients was identified as the ethereal glucuronide of salicylamide. A small and extremely variable amount of the original drug also was recovered in the urine. No other metabolite could be detected. No metabolite of salicylic acid was detected, indicating that the substance was not converted to salicylic acid and that the pharmacological action could not be due to the latter substance. ER -