RT Journal Article
SR Electronic
T1 A STUDY OF THE METABOLISM OF Cl4 SALICYLAMIDE IN THE HUMAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 433
OP 439
VO 106
IS 4
A1 H. George Mandel
A1 Paul K. Smith
A1 Victor W. Rodwell
YR 1952
UL http://jpet.aspetjournals.org/content/106/4/433.abstract
AB Salicylamide-C14 has been prepared in this laboratory from C14 salicylic acid. The major urinary metabolite after the oral administration of 300 mgm. of the drug to cancer patients was identified as the ethereal glucuronide of salicylamide. A small and extremely variable amount of the original drug also was recovered in the urine. No other metabolite could be detected. No metabolite of salicylic acid was detected, indicating that the substance was not converted to salicylic acid and that the pharmacological action could not be due to the latter substance.