TY - JOUR T1 - ACTIONS AND ADDICTION LIABILITIES OF ALPHA-ACETYLMETHADOLS IN MAN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 458 LP - 465 VL - 105 IS - 4 AU - H. F. Fraser AU - Harris Isbell Y1 - 1952/08/01 UR - http://jpet.aspetjournals.org/content/105/4/458.abstract N2 - 1. dl-, d- and l-Alpha-acetylmethadol possess addiction liability. 2. Single subcutaneous or intravenous doses of d-alpha-acetylmethadol in former morphine addicts promptly induced a train of morphine-like effects which disappeared in less than 24 hours. Oral administration of d-alpha-acetyl-methadol was less efficacious than subcutaneous or intravenous administration. 3. Definite morphine-like effects did not appear for four to six hours after subcutaneous or intravenous injections of l-alpha-acetylmethadol. Once developed, the effects of a single dose persisted for 24 to 72 hours. After oral administration of l-alpha-acetylmethadol, morphine-like effects were observed one hour after administration and persisted for 48 hours. 4. Due to the long length of action, cumulative toxic effects will appear if doses of l-alpha-acetylmethadol are not widely spaced in time. ER -