PT  - JOURNAL ARTICLE
AU  - Thomas C. Butler
AU  - Darien Mahaffee
AU  - Collins Mahaffee
TI  - THE ROLE OF THE LIVER IN THE METABOLIC DISPOSITION OF MEPHOBARBITAL
DP  - 1952 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 364--369
VI  - 106
IP  - 3
4099  - http://jpet.aspetjournals.org/content/106/3/364.short
4100  - http://jpet.aspetjournals.org/content/106/3/364.full
SO  - J Pharmacol Exp Ther1952 Nov 01; 106
AB  - By measurement of concentrations of the drugs in plasma, a study has been made of the effect of partial hepatectomy on the metabolic disposition of mephobarbital and phenobarbital in the rat. Partial hepatectomy has such a large effect on the rate of disappearance of mephobarbital and on the rate of production of phenobarbital from mephobarbital as to suggest that the liver is the principal, if not the only, site of the demethylation of mephobarbital. Mephobarbital is not as completely converted to phenobarbital in the rat as in the dog.