TY - JOUR T1 - THE ROLE OF BODY FAT IN LIMITING THE DURATION OF ACTION OF THIOPENTAL JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 421 LP - 426 VL - 105 IS - 4 AU - Bernard B. Brodie AU - Eleonore Bernstein AU - Lester C. Mark Y1 - 1952/08/01 UR - http://jpet.aspetjournals.org/content/105/4/421.abstract N2 - Following the intravenous administration of thiopental to dogs, the anesthetic is rapidly distributed throughout the various organ tissues, including the central nervous system. The concentration of the drug in the various tissues declines rapidly and in a parallel manner. The concentration of thiopental in fat, at first low, rises rapidly so that the major part of the drug is ultimately localized in the body fat. It is concluded that thiopental is ultra-short acting after a small dose, not because of its metabolic transformation, which is slow, but because it is rapidly localized in fat. ER -