PT  - JOURNAL ARTICLE
AU  - Bernard B. Brodie
AU  - Eleonore Bernstein
AU  - Lester C. Mark
TI  - THE ROLE OF BODY FAT IN LIMITING THE DURATION OF ACTION OF THIOPENTAL
DP  - 1952 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 421--426
VI  - 105
IP  - 4
4099  - http://jpet.aspetjournals.org/content/105/4/421.short
4100  - http://jpet.aspetjournals.org/content/105/4/421.full
SO  - J Pharmacol Exp Ther1952 Aug 01; 105
AB  - Following the intravenous administration of thiopental to dogs, the anesthetic is rapidly distributed throughout the various organ tissues, including the central nervous system. The concentration of the drug in the various tissues declines rapidly and in a parallel manner. The concentration of thiopental in fat, at first low, rises rapidly so that the major part of the drug is ultimately localized in the body fat. It is concluded that thiopental is ultra-short acting after a small dose, not because of its metabolic transformation, which is slow, but because it is rapidly localized in fat.