RT Journal Article
SR Electronic
T1 EXPERIMENTAL DIABETES PRODUCED BY 8-HYDROXYQUINOLINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 404
OP 411
VO 104
IS 4
A1 Mary A. Root
A1 K. K. Chen
YR 1952
UL http://jpet.aspetjournals.org/content/104/4/404.abstract
AB 1. Intravenous administration of 8-hydroxyquinoline produces pancreatic diabetes in a small percentage of rabbits but not in rats, hamsters, guinea pigs, cats or dogs. 2. Methylene blue administered intravenously immediately before the injection of 8-hydroxyquinoline increases the incidence of diabetes in rabbits. 3. 8-Hydroxyquinoline-5-sulfonic acid, 8-chloroquinoline and 8-methoxyquinoline have no diahetogenic action. A slight, transient hyperglycemia occurs with 2-hydioxyquinoline. 4. Diphenylthiocarbazone produces diabetes in rabbits if a large enough dose can be administered, but the low solubility of this compound makes it difficult to employ.