RT Journal Article
SR Electronic
T1 SPASMOLYTIC ACTION OF BICYCLIC BASIC ALCOHOL ESTERS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 284
OP 290
VO 104
IS 3
A1 Randall, Lowell O.
A1 Benson, Wilbur M.
A1 Stefko, Paul L.
YR 1952
UL http://jpet.aspetjournals.org/content/104/3/284.abstract
AB A series of eighteen esters of bicyclic amino alcohols have been assayed for spasmolytic activity. The quinuclidinol esters and azabicyclo-octanol esters have anticholinergic activity of the order of atrophic while the azabicyclononanol esters are considerably weaker. The quaternary salt, Ro 2-3773 (1-methyl-3-benziloyloxy-quinuclidinium bromide), has an anticholinergic activity similar to atropine. Ro 2-3773 is equal to atropine in antiacetylcholine activity on isolated intestine and in antiacetylcholine and antivagal activity as measured on arterial pressure; it is slightly stronger in antisalivary and antilacrimating properties; and it is less active in protecting against methacholine-induced bronchospasm. Ganglionic blocking action is about equal to that of TEA and occurs at doses thirty times higher than the vagal blocking dose.