PT  - JOURNAL ARTICLE
AU  - D. D. Bonnycastle
AU  - C. S. Leonard
TI  - AN ESTIMATION OF THE ACTIVITY OF ANALGETIC MATERIALS
DP  - 1950 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 141--145
VI  - 100
IP  - 2
4099  - http://jpet.aspetjournals.org/content/100/2/141.short
4100  - http://jpet.aspetjournals.org/content/100/2/141.full
SO  - J Pharmacol Exp Ther1950 Oct 01; 100
AB  - 1. A relatively simple procedure is described for the estimation of the activity of analgetic drugs, utilizing the rat as the test animal. 2. The method will discriminate between weak analgetic drugs, like aspirin, and more active members of the analgetic group, like morphine. 3. In discussing the interpretation of results the data from such experiments may be treated either as a graded response or a quantal one. The estimations of activity obtained from these two different treatments are not identical.