RT Journal Article
SR Electronic
T1 ALYPINE, EUCAINE, HOLOCAINE, NOVOCAINE, AND STOVAINE ON THE BLADDER
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 243
OP 250
VO 10
IS 4
A1 J. A. WADDELL
YR 1917
UL http://jpet.aspetjournals.org/content/10/4/243.abstract
AB 1. Alypine, alpha and beta eucaine, holocaine, novocaine, and stovaine stimulate the excised bladder when suspended in oxygenated Tyrode's solution at body temperature. 2. Compared with cocaine, the stimulating action of beta eucaine is approximately one-seventh; of novocaine, one-sixth; of alypine, alpha eucaine, and stovaine, one-third; and of holocaine, two-thirds. 3. Mixtures of the synthetic cocaine substitutes with each other give simple summation on the excised bladder. 4. Combinations with epinephrine exhibit simple antagonism and with pituitrin simple summation, on the excised bladder. 5. Paralysis of the parasympathetic myoneural junctions by atropine does not alter the response of the excised bladder to any of the drugs of this series. 6. The conclusion drawn is that these drugs act on the muscle directly, since their effects are the opposite to those of sympathetic stimulation and are unchanged by paralysis of the parasympathetic myoneural junctions.