RT Journal Article
SR Electronic
T1 THE FATE OF INTRATHECAL PROCAINE AND THE SPINAL FLUID LEVEL REQUIRED FOR SURGICAL ANESTHESIA
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 78
OP 82
VO 100
IS 1
A1 Helrich, Martin
A1 Papper, E. M.
A1 Brodie, Bernard B.
A1 Fink, Marvin
A1 Rovenstine, E. A.
YR 1950
UL http://jpet.aspetjournals.org/content/100/1/78.abstract
AB 1. The decline of procaine concentration which limits the duration of spinal anesthesia is not due to chemical breakdown of the drug in the spinal fluid, but to absorption into the systemic circulation where it is metabolized to p-aminobenzoic acid and diethylaminoethanol. 2. The concentrations of procaine at various levels of the subarachnoid space decline at the same rate. 3. There is a critical concentration of procaine, about 0.2 mgm. per ml., which is necessary for sensory anesthesia.