RT Journal Article
SR Electronic
T1 THE RELATIONSHIP BETWEEN CHOLINESTERASE ACTIVITY AND BRAIN PERMEABILITY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1
OP 4
VO 102
IS 1
A1 Margaret E. Greig
A1 Thomas C. Mayberry
YR 1951
UL http://jpet.aspetjournals.org/content/102/1/1.abstract
AB The administration of physostigmine to mice prior to intravenous injection of either barbital or glucochloralose has been found to reduce the anesthetic lag by about 50 per cent. In the case of barbital, this is accompanied by an increase in the rate of penetration of the drug into the brain. This increased permeability of the brain to the anesthetic is attributed to inhibition of cholinesterase activity by physostigmine.