TY - JOUR T1 - TOXICITY OF PHOSPHATES, IN RELATION TO BLOOD CALCIUM AND TETANY JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 105 LP - 120 VL - 10 IS - 2 AU - CARL BINGER Y1 - 1917/08/01 UR - http://jpet.aspetjournals.org/content/10/2/105.abstract N2 - 1. Solutions of orthophosphoric acid and its sodium salts, when injected intravenously in dogs, cause a diminution in the amount of calcium in the serum. 2. The degree of diminution in calcium content or serum depends upon the amount of phosphate introduced. 3. When the phosphate solution is injected in amounts equivalent to 150 mgm. phosphorus per kilogram the serum calcium drops from its normal level of 10 mgm. per 100 cc. to approximately 6 mgm. 4. At this level a condition of tetany supervenes, provided the neutral or alkaline salts have been injected. With acid phosphate solutions, the calcium drop occurs unaccompanied by tetany. 5. The region at which the phosphate solutions become toxic when injected in the doses here employed lies in the neighborhood of PH 6.0. ER -