RT Journal Article
SR Electronic
T1 THE RENAL RESPONSE TO THYROXIN ADMINISTRATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 283
OP 286
VO 101
IS 3
A1 Handley, Carroll A.
A1 Moyer, John H.
A1 Kennedy, Orinda
A1 Costa, Patsy
YR 1951
UL http://jpet.aspetjournals.org/content/101/3/283.abstract
AB The daily intravenous administration of thyroxin to dogs causes a marked increase in the glomerular filtration rate, renal plasma flow, tubular transport of dextrose and p-aminohippurate and an increase in renal oxygen consumption. All these changes are proportional and appear to be best explained by assuming that thyroxin increases the number of functional nephrons in the kidney and not to a direct effect on enzyme systems of the renal tubules. Such a concept is in accord with the diuretic action of thyroxin.