TY - JOUR T1 - CHEMICAL CORRELATIVES OF DIGITALIS POTENCY IN MAN, CAT AND PIGEON JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 167 LP - 175 VL - 101 IS - 2 AU - Louis J. Sciarini AU - William T. Salter Y1 - 1951/02/01 UR - http://jpet.aspetjournals.org/content/101/2/167.abstract N2 - After suitable fractionation, the digitoxin in samples of Digitalis purpurea tincture has been estimated by a fluorometric procedure. Among five preparations so studied, the estimated digitoxin agreed well with the oral potency in man determined by Dr. Harry Gold. The chemical values varied between 10 and 19 per cent of the intravenous lethal equivalent in cat or pigeon. Because the digitoxin content of powdered digitalis leaf is not constant, the intravenous lethal dose in animals is a poor index of its oral potency in man. ER -