PT  - JOURNAL ARTICLE
AU  - Alkadhi, Karim A.
TI  - Synaptic plasticity and cognitive ability in experimental adult-onset hypothyroidism
AID  - 10.1124/jpet.123.001887
DP  - 2024 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - JPET-MR-2023-001887
4099  - http://jpet.aspetjournals.org/content/early/2024/03/20/jpet.123.001887.short
4100  - http://jpet.aspetjournals.org/content/early/2024/03/20/jpet.123.001887.full
AB  - Adult-onset hypothyroidism impairs normal brain function. Research on animal models of hypothyroidism has revealed critical information on how deficiency of thyroid hormones impacts the electrophysiological and molecular functions of the brain, which lead to the well-known cognitive impairment in untreated hypothyroid patients. Currently, such information can only be obtained from experiments on animal models of hypothyroidism. This review summarizes important research findings that pertain to understanding the clinical cognitive consequences of hypothyroidism, which will provide a guiding path for therapy of hypothyroidism. Significance Statement Cognitive impairment occurs during adult-onset hypothyroidism in both humans and animal models. Findings from animal studies validate clinical findings showing impaired LTP, decreased CaMKII and increased calcineurin. Such findings can only be gleaned from animal experiments to show how hypothyroidism produces clinical symptoms.