PT  - JOURNAL ARTICLE
AU  - Jiao Qu
AU  - Li Yue
AU  - Jian Gao
AU  - Hongwei Yao
TI  - Perspectives on Wnt signal pathway in the pathogenesis and therapeutics in chronic obstructive pulmonary disease
AID  - 10.1124/jpet.118.256222
DP  - 2019 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - jpet.118.256222
4099  - http://jpet.aspetjournals.org/content/early/2019/04/05/jpet.118.256222.short
4100  - http://jpet.aspetjournals.org/content/early/2019/04/05/jpet.118.256222.full
AB  - Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with progressive airflow limitation and lung function decline. The pathogenic mechanisms for this disease include oxidative stress, inflammatory responses, disturbed protease/anti-protease equilibrium, apoptosis/proliferation imbalance, senescence, autophagy, metabolic reprogramming, and mitochondrial dysfunction. Wnt signaling pathway is an evolutionarily conserved signaling pathway, which is abnormal in COPD, including chronic bronchitis and pulmonary emphysema. Furthermore, Wnt signaling has been shown to modulate aforementioned cellular processes involved in COPD. In this perspective, we have provided the updated understanding on the crosstalk between Wnt signal and these cellular processes, and highlighted the crucial role of Wnt signal during the development of COPD. We have also discussed the potential directions for future translational and pharmacological therapeutics by targeting Wnt signal for the prevention and treatment of this disease.