RT Journal Article
SR Electronic
T1 Targeting Glycine Reuptake in Alcohol Seeking and Relapse
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 202
OP 211
DO 10.1124/jpet.117.244822
VO 365
IS 1
A1 Valentina Vengeliene
A1 Martin Roßmanith
A1 Tatiane T. Takahashi
A1 Daniela Alberati
A1 Berthold Behl
A1 Anton Bespalov
A1 Rainer Spanagel
YR 2018
UL http://jpet.aspetjournals.org/content/365/1/202.abstract
AB It has recently been demonstrated that pharmacological blockade of the glycine transporter 1 (GlyT1) reduced alcohol intake and relapse in rats. The aim of the present study was to further explore the role of GlyT1 in alcohol relapse-like behavior. For this purpose we used three different GlyT1 blockers—SSR504734, A-1246399, and RO4993850—and tested their effect on alcohol-seeking and relapse-like consumption. Two behavioral models, the alcohol deprivation effect model and the cue-induced reinstatement model, were used. Our data show that all three GlyT1 blockers reduce relapse-like alcohol consumption and cause either minimal or no side effects, measured as changes in home-cage activity, water intake, and body weight. In the reinstatement test, GlyT1 blockers completely abolished alcohol-seeking responses. Furthermore, we tested other drug/cue associations and found that cocaine-seeking responses were also abolished by GlyT1 blockade. Our data confirm that GlyT1 can be used as a target to develop novel anticraving and antirelapse drugs.