PT  - JOURNAL ARTICLE
AU  - GORDON A. ALLES
AU  - CHARLES H. ELLIS
TI  - COMPARATIVE CENTRAL DEPRESSANT ACTIONS OF SOME 5-PHENYL-5-ALKENYL BARBITURIC ACIDS
DP  - 1949 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 352--359
VI  - 95
IP  - 3
4099  - http://jpet.aspetjournals.org/content/95/3/352.short
4100  - http://jpet.aspetjournals.org/content/95/3/352.full
SO  - J Pharmacol Exp Ther1949 Mar 01; 95
AB  - 1. Additional evidence, from studies of the comparative central actions of phenyl alkenyl barbituric acids, is presented to show that the mechanism which raises the convulsant threshold is different from the mechanism producing hypnosis. 2. Anticonvulsant activity of the phenyl alkenyl barbituric acids appears to be maximal with the four-membered straight alkyl chain compound, 5-phenyl-5-crotyl barbituric acid. 3. The phenyl crotyl compound is more soluble in water than the corresponding phenyl butyl compound, and is more effectively absorbed after oral administration, when both are given in the form of their free acids. 1949 by The American Society for Pharmacology and Experimental Therapeutics