PT  - JOURNAL ARTICLE
AU  - Lawrence C. Weaver
AU  - William M. Alexander
AU  - Benedict E. Abreu
AU  - Alice B. Richards
AU  - W. Ralph Jones
AU  - Robert W. Begley
TI  - THE MECHANISM OF THE HYPOTENSIVE ACTION OF NARCOTINE HYDROCHLORIDE
DP  - 1958 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 287--295
VI  - 123
IP  - 4
4099  - http://jpet.aspetjournals.org/content/123/4/287.short
4100  - http://jpet.aspetjournals.org/content/123/4/287.full
SO  - J Pharmacol Exp Ther1958 Aug 01; 123
AB  - Narcotine hydrochloride produces systemic vasodepression which is incompletely blocked by diphenhydramine but is unaffected by atropinization, mid-cervical vagotomy and/or carotid sinus and body denervation. It also increases coronary blood flow and femoral blood flow. Coronary blood flow is increased without significant effects on the other cardiovascular variables. Bronchoconstriction is produced in the dog. Tachyphylaxis develops to the vascular and bronchial effects of this compound. In addition, cross-tachyphylaxis develops between marcotine and 48/80. It is concluded that tue mechanism for these changes is due to histamine liberation.