RT Journal Article
SR Electronic
T1 Sphingolipids: de novo synthesis and signaling in blood pressure homeostasis
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP jpet.116.233205
DO 10.1124/jpet.116.233205
A1 Anna Cantalupo
A1 Annarita Di Lorenzo
YR 2016
UL http://jpet.aspetjournals.org/content/early/2016/06/16/jpet.116.233205.abstract
AB Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunological, inflammatory and cardiovascular disorders. In this review, we will discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and will focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling will also be discussed.