RT Journal Article
SR Electronic
T1 Fibromyalgia, a syndrome in search of pathogenesis and therapy
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP jpet.115.227298
DO 10.1124/jpet.115.227298
A1 Theoharis C Theoharides
A1 Irene Tsilioni
A1 Lauren Arbetman
A1 Smaro Panagiotidou
A1 Julia M Stewart
A1 Rae M Gleason
A1 Irwin J Russell
YR 2015
UL http://jpet.aspetjournals.org/content/early/2015/08/25/jpet.115.227298.abstract
AB Fibromyalgia Syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, non-articular, pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, as well as cognitive dysfunction. The diagnostic criteria have changed repeatedly and there is neither definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.