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Future Table of Contents: September 2008; 326 (3)

CENTENNIAL PERSPECTIVE

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

CENTENNIAL PERSPECTIVE

James E. Barrett and Jack Bergman

Peter B. Dews and Pharmacological Studies on Behavior (Fast Forward 10 June 2008)

BEHAVIORAL PHARMACOLOGY

Gail Pereira Do Carmo, Robin Polt, Edward J. Bilsky, Kenner C. Rice, and S. Stevens Negus

Behavioral Pharmacology of the Mu/Delta Opioid Glycopeptide MMP2200 in Rhesus Monkeys (Fast Forward 29 May 2008)

Ziva D Cooper, Yen N Truong, Yong-Gong Shi, and James H Woods

Morphine deprivation increases self-administration of the fast- and short-acting mu-opioid receptor agonist remifentanil in the rat (Fast Forward 30 May 2008)

Roberto Coccurello, Antonio Caprioli, Roberto Conti, Orlando Ghirardi, Franco Borsini, Paolo Carminati, and Anna Moles

Olanzapine but not the novel atypical antipsychotic ST2472 chronic administration induces weight gain, hyperphagia and metabolic dysregulation in mice (Fast Forward 20 June 2008)

CARDIOVASCULAR

Lorraine Yau, Peter Molnar, Michael C. Moon, Shelly Buhay, Jeffrey P. Werner, Katerina Molnar, Laura Saward, Dario Del Rizzo, and Peter Zahradka

Meta-Iodobenzylguanidine, an Inhibitor of Arginine-dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia (Fast Forward 3 June 2008)

Christopher Morrey, Rima Estephan, Geoffrey W. Abbott, and Roberto Levi

Cardioprotective Effect of Histamine H3-Receptor Activation: Pivotal Role of G beta gamma-Dependent Inhibition of Voltage-Operated Ca2+ Channels (Fast Forward 3 June 2008)

Marcella Rocchetti, Matteo Alemanni, Gaspare Mostacciuolo, Paolo Barassi, Claudia Altomare, Riccardo Chisci, Rosella Micheletti, Patrizia Ferrari, and Antonio Zaza

Modulation of sarcoplasmic reticulum function by istaroxime (PST2744) in a pressure-overload heart failure model (Fast Forward 6 June 2008)

Qinghua Zeng, Qingwei Zhou, Fanrong Yao, Stephen T. O'Rourke, and Chengwen Sun

Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide (Fast Forward 6 June 2008)

Huige Li, Marcus Hortmann, Andreas Daiber, Matthias Oelze, Mir Abolfazl Ostad, Petra M Schwarz, Hui Xu, Ning Xia, Andrei L Kleschyov, Christian Mang, Ascan Warnholtz, Thomas Munzel, and Ulrich Forstermann

COX2-selective and non-selective NSAIDs induce oxidative stress by upregulating vascular NADPH oxidases (Fast Forward 13 June 2008)

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi, and Kenji Kuwabara

A long-acting and highly selective prostacyclin receptor agonist prodrug, NS-304, ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, MRE-269, on rat pulmonary artery (Fast Forward 13 June 2008)

Chin-Wei Chiao, Rita C. Tostes, and R. Clinton Webb

P2X7 receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 beta release (Fast Forward 16 June 2008)

Wieslaw Kozak, Anna Kozak, Maribeth H Johnson, Hazem F Elewa, and Susan C Fagan

Vascular protection with candesartan after experimental stroke in hypertensive rats: A dose-response study (Fast Forward 17 June 2008)

Young Mi Seok, Inji Baek, Yong-Hoon Kim, Yeon-Shin Jeong, In-Jung Lee, Dong Hyun Shin, Young Hyun Hwang, and InKyeom Kim

Isoflavone attenuates vascular contraction through inhibition of RhoA/Rho-kinase signaling pathway (Fast Forward 24 June 2008)

Julie L. Hawkins, Michael D. Robbins, Laurie C. Warren, Donghui Xia, Stephen F. Petras, James J. Valentine, Alison H. Varghese, Ing-Kae Wang, Timothy A. Subashi, Lorraine D. Shelly, Bruce A. Hay, Katherine T. Landschulz, Kieran F. Geoghegan, and H. James Harwood

Pharmacologic inhibition of site-1 protease activity inhibits SREBP processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals (Fast Forward 24 June 2008)

CELLULAR AND MOLECULAR

Richard R. Almon, Eric Yang, William Lai, Ioannis P Androulakis, Debra C DuBois, and William J. Jusko

Circadian Variations in Liver Gene Expression: Relationships to Drug Actions (Fast Forward 18 June 2008)

Andreas Koeberle, Ulf Siemoneit, Ulrike Buehring, Hinnak Northoff, Stefan Laufer, Wolfgang Albrecht, and Oliver Werz

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1 (Fast Forward 11 June 2008)

Nora Bijl, Saskia Scheij, Sander M. Houten, Rolf G. Boot, Albert K. Groen, and Johannes M. F. G. Aerts

The glucosylceramide synthase inhibitor AMP-DNM induces SREBP regulated gene expression and cholesterol synthesis in HepG2 cells (Fast Forward 12 June 2008)

Telma Roque, Emilie Boncoeur, Vinciane Saint-Criq, Elise Bonvin, Annick Clement, Olivier Tabary, and Jacky Jacquot

Pro-inflammatory effect of sodium 4-phenylbutyrate in Delta F508-CFTR lung epithelial cells: Involvement of ERK1/2 and JNK signaling (Fast Forward 23 June 2008)

Andrea Strasser, Hans-Joachim Wittmann, and Roland Seifert

Ligand-Specific Contribution of the N-Terminus and E2-Loop to Pharmacological Properties of the Histamine H1-Receptor (Fast Forward 24 June 2008)

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Melissa A Burmeister, Michael A Ansonoff, John E Pintar, and Daniel R Kapusta

Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension and diuresis are absent in N/OFQ peptide (NOP) receptor knockout (NOP-/-) mice (Fast Forward 6 June 2008)

Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara, and Koji Takeuchi

Phosphodiesterase Isozymes Involved in Regulation of HCO3- Secretion in Isolated Mouse Stomach In Vitro (Fast Forward 12 June 2008)

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

Daigen Xu, Steven E Rowland, Patsy Clark, Andre Giroux, Bernard Cote, Sebastien Guiral, Myriam Salem, Yves Ducharme, Richard W Friesen, Nathalie Methot, Joseph Mancini, Laurent Audoly, and Denis Riendeau

MF63 {2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile}, a selective microsomal prostaglandin E synthase 1 inhibitor, relieves pyresis and pain in preclinical models of inflammation (Fast Forward 4 June 2008)

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Fetweh H. Al-Saleem, Denise M Ancharski, Easwaran Ravichandran, Suresh G Joshi, Ajay K Singh, Yujing Gong, and Lance L Simpson

The Role of Systemic Handling in the Pathophysiologic Actions of Botulinum Toxin (Fast Forward 6 June 2008)

Jitesh D Kawedia, Mengmeng Jiang, Amit Kulkarni, Holly E Waechter, Karl S Matlin, Giovanni M Pauletti, and Anil G. Menon

The PKA pathway contributes to Hg++ induced alterations in phosphorylation and subcellular distribution of occludin associated with increased tight junction permeability of salivary epithelial cell monolayers (Fast Forward 12 June 2008)

Koji Abe, ARLENE BRIDGES, Wei Yue, and Kim L. R. Brouwer

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison to In Vivo Biliary Clearance (Fast Forward 23 June 2008)

NEUROPHARMACOLOGY

Carol S Surowy, Torben R Neelands, Bruce R Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L Chu, Heath A McDonald, Melissa Vos, Wende Niforatos, Erol K Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P Sullivan, Michael F Jarvis, and Connie R Faltynek

ABT-102 ((R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea) Blocks Polymodal Activation of TRPV1 Receptors In Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons In Vivo (Fast Forward 30 May 2008)

Alan R. Gintzler, Stephen A Schnell, Daya S Gupta, Nai-Jiang Liu, and Martin W Wessendorf

Relationship of spinal dynorphin neurons to delta opioid receptors and estrogen receptor alpha; anatomical basis for ovarian sex steroid opioid antinociception (Fast Forward 9 June 2008)

Hiroshi Onozuka, Akira Nakajima, Kentaro Matsuzaki, Ryong-Woon Shin, Koichi Ogino, Daisuke Saigusa, Naomi Tetsu, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, and Yasushi Ohizumi

Nobiletin, a citrus flavonoid, improves memory impairment and A beta pathology in a transgenic mouse model of Alzheimer's disease (Fast Forward 10 June 2008)

Yan Xia, Cheng Z. Wang, Jie Liu, Noelle C. Anastasio, and Kenneth M. Johnson

Lithium Protection of Phencyclidine-induced Neurotoxicity in Developing Brain: The Role PI-3K/Akt and MEK/ERK Signaling Pathways (Fast Forward 10 June 2008)

Wei Hu, Laura Saba, Katherina Kechris, Sanjiv V Bhave, Paula L Hoffman, and Boris Tabakoff

Genomic Insights into Acute Alcohol Tolerance (Fast Forward 11 June 2008)

Xiao Ru Chen, Valerie C Besson, Tiphaine Beziaud, Michel Plotkine, and Catherine Marchand-Leroux

Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury (Fast Forward 18 June 2008)

Jeffrey M. Witkin, Beth Levant, Agustin Zapata, Rafal Kaminski, and Maciej Gasior

The DopamineD3/D2 Agonist R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD-128,907] Protects Against Acute and Cocaine Kindled Seizures in Mice: Further Evidence for the Involvement of D3 Receptors (Fast Forward 19 June 2008)

Urszula Baranowska, Manfred Gothert, Radoslaw Rudz, and Barbara Malinowska

Methanandamide allosterically inhibits in vivo the function of peripheral nicotinic acetylcholine receptors containing the alpha7-subunit. (Fast Forward 20 June 2008)

Rosemarie Roeloffs, Alan D Wickenden, Christopher Crean, Steven Werness, Grant McNaughton-Smith, James Stables, James O McNamara, Neil Ghodadra, and Greg C Rigdon

In vivo profile of ICA-27243, a potent and selective KCNQ2/Q3 activator in rodent anticonvulsant models (Fast Forward 24 June 2008)

TOXICOLOGY

Joseph T Dever and Adnan A Elfarra

L-Methionine Toxicity in Freshly-Isolated Mouse Hepatocytes is Gender-Dependent and Mediated in Part by Transamination (Fast Forward 13 June 2008)

Jin Yan and Barbara F. Hales

p38 and JNK Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways Play Distinct Roles in the Response of Organogenesis Stage Embryos to a Teratogen (Fast Forward 24 June 2008)