Abstract
The influence of non-competitive NMDA receptor antagonist, 1-amino-3,5-dimethyl-adamantane (memantine), and glycineB site antagonist, 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone (L-701,324), on the development of ethanol dependence was investigated in Wistar rats. The development of ethanol dependence was induced by intragastric administration of 20% w/v ethanol, three times a day at increasing doses. The results were quantified using withdrawal audiogenic seizures, 12 h after the last ethanol administration. Memantine (3.75 or 7.5 mg/kg) and L-701,324 (2.5 or 5 mg/kg), given before ethanol administration, prevented the development of ethanol dependence. Our results support the data that NMDA receptors are involved in the development of ethanol dependence.
MeSH terms
-
2-Amino-5-phosphonovalerate / administration & dosage
-
2-Amino-5-phosphonovalerate / pharmacology
-
2-Amino-5-phosphonovalerate / therapeutic use
-
Adaptation, Biological
-
Alcohol-Related Disorders / drug therapy*
-
Animals
-
Disease Models, Animal
-
Ethanol / administration & dosage
-
Ethanol / pharmacology*
-
Excitatory Amino Acid Antagonists / administration & dosage
-
Excitatory Amino Acid Antagonists / pharmacology
-
Excitatory Amino Acid Antagonists / therapeutic use*
-
Male
-
Memantine / administration & dosage
-
Memantine / therapeutic use*
-
Quinolones / administration & dosage
-
Quinolones / pharmacology
-
Quinolones / therapeutic use
-
Rats
-
Rats, Wistar
-
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
-
Receptors, N-Methyl-D-Aspartate / metabolism
-
Self Administration
Substances
-
Excitatory Amino Acid Antagonists
-
Quinolones
-
Receptors, N-Methyl-D-Aspartate
-
Ethanol
-
2-Amino-5-phosphonovalerate
-
L 701324
-
Memantine