HIGHLIGHTED PAPERS:

BEHAVIORAL PHARMACOLOGY:

Lisa Krugner-Higby, Butch KuKanich, Brynn Schmidt, Timothy D. Heath, Carolyn Brown, and Lesley J. Smith

Pharmacokinetics and Behavioral Effects of an Extended-Release, Liposome-Encapsulated Preparation of Oxymorphone in Rhesus Macaques
J Pharmacol Exp Ther 2009 330: 135-141. Published online April 7, 2009; 10.1124/jpet.108.150052 [Abstract] [Full Text] [PDF]  

Zhihua Xie and Gregory M. Miller

A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain
J Pharmacol Exp Ther 2009 330: 316-325. Published online April 13, 2009; 10.1124/jpet.109.153775 [Abstract] [Full Text] [PDF] [Data Supplement]   

CARDIOVASCULAR:

Mohamed Izikki, Bernadette Raffestin, Juergen Klar, Armin Hatzelmann, Degenhard Marx, Hermann Tenor, Patricia Zadigue, Serge Adnot, and Saadia Eddahibi

Effects of Roflumilast, a Phosphodiesterase-4 Inhibitor, on Hypoxia- and Monocrotaline-Induced Pulmonary Hypertension in Rats
J Pharmacol Exp Ther 2009 330: 54-62. Published online April 22, 2009; 10.1124/jpet.108.148742 [Abstract] [Full Text] [PDF]  

Philip Wenzel, Eberhard Schulz, Tommaso Gori, Mir A. Ostad, Falk Mäthner, Stefan Schildknecht, Sebastian Göbel, Matthias Oelze, Dirk Stalleicken, Ascan Warnholtz, Thomas Münzel, and Andreas Daiber

Monitoring White Blood Cell Mitochondrial Aldehyde Dehydrogenase Activity: Implications for Nitrate Therapy in Humans
J Pharmacol Exp Ther 2009 330: 63-71. Published online April 3, 2009; 10.1124/jpet.108.149716 [Abstract] [Full Text] [PDF] [Data Supplement]   

Genya Huang, Chufan Luo, Xingyuan Gu, Zhongkai Wu, Zhiping Wang, Zhiming Du, Chengheng Hu, and Lilong Tang

Mechanical Strain Induces Expression of C-Reactive Protein in Human Blood Vessels
J Pharmacol Exp Ther 2009 330: 206-211. Published online April 27, 2009; 10.1124/jpet.109.150961 [Abstract] [Full Text] [PDF]  

Jasdeep S. Dhaliwal, Adeleke M. Badejo, Jr., David B. Casey, Subramanyam N. Murthy, and Philip J. Kadowitz

Analysis of Pulmonary Vasodilator Responses to SB-772077-B [4-(7-((3-Amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a Novel Aminofurazan-Based Rho Kinase Inhibitor
J Pharmacol Exp Ther 2009 330: 334-341. Published online April 15, 2009; 10.1124/jpet.109.151449 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Xiaoping Zhang, Guansong Wang, Denis J. Dupré, Yumei Feng, Mélanie Robitaille, Eric Lazartigues, Ying-Hong Feng, Terence E. Hébert, and Guangyu Wu

Rab1 GTPase and Dimerization in the Cell Surface Expression of Angiotensin II Type 2 Receptor
J Pharmacol Exp Ther 2009 330: 109-117. Published online April 8, 2009; 10.1124/jpet.109.153460 [Abstract] [Full Text] [PDF]  

Thomas A. Morinelli, Ryan T. Kendall, Louis M. Luttrell, Linda P. Walker, and Michael E. Ullian

Angiotensin II-Induced Cyclooxygenase 2 Expression in Rat Aorta Vascular Smooth Muscle Cells Does Not Require Heterotrimeric G Protein Activation
J Pharmacol Exp Ther 2009 330: 118-124. Published online April 7, 2009; 10.1124/jpet.109.151829 [Abstract] [Full Text] [PDF]  

Ingrid P. Fricks, Rhonda L. Carter, Eduardo R. Lazarowski, and T. Kendall Harden

G_i-Dependent Cell Signaling Responses of the Human P2Y₁₄ Receptor in Model Cell Systems
J Pharmacol Exp Ther 2009 330: 162-168. Published online April 1, 2009; 10.1124/jpet.109.150730 [Abstract] [Full Text] [PDF]  

Maninder Chopra, Yi Yao, Timothy J. Blake, David. R. Hampson, and Edwin C. Johnson

The Neuroactive Peptide N-Acetylaspartylglutamate Is Not an Agonist at the Metabotropic Glutamate Receptor Subtype 3 of Metabotropic Glutamate Receptor
J Pharmacol Exp Ther 2009 330: 212-219. Published online April 23, 2009; 10.1124/jpet.109.152553 [Abstract] [Full Text] [PDF]  

Ken Shimamura, Hidefumi Kitazawa, Yasuhisa Miyamoto, Maki Kanesaka, Akira Nagumo, Ryo Yoshimoto, Katsumi Aragane, Naomi Morita, Tomoyuki Ohe, Toshiyuki Takahashi, Tsuyoshi Nagase, Nagaaki Sato, and Shigeru Tokita

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a Potent Inhibitor for Mammalian Elongase of Long-Chain Fatty Acids Family 6: Examination of Its Potential Utility as a Pharmacological Tool
J Pharmacol Exp Ther 2009 330: 249-256. Published online April 9, 2009; 10.1124/jpet.109.150854 [Abstract] [Full Text] [PDF] [Data Supplement]   

Haitian Quan, Houfu Liu, Chuan Li, and Liguang Lou

1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) Enhances the Cytotoxicity of Combretastatin A4 Independently of Mitogen-Activated Protein Kinase Kinase
J Pharmacol Exp Ther 2009 330: 326-333. Published online April 18, 2009; 10.1124/jpet.109.153320 [Abstract] [Full Text] [PDF]  

Kimberly J. Duncan, Kristin A. Eckert, and Gary A. Clawson

Mechanisms of Growth Inhibition in Human Papillomavirus Positive and Negative Cervical Cancer Cells by the Chloromethyl Ketone Protease Inhibitor, Succinyl-Alanine-Alanine-Proline-Phenylalanine Chloromethyl Ketone
J Pharmacol Exp Ther 2009 330: 359-366. Published online April 28, 2009; 10.1124/jpet.108.149765 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Anson K. Abraham, Donald E. Mager, Xiang Gao, Mei Li, David R. Healy, and Tristan S. Maurer

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Parathyroid Hormone-Calcium Homeostasis in Rats and Humans
J Pharmacol Exp Ther 2009 330: 169-178. Published online April 22, 2009; 10.1124/jpet.109.152033 [Abstract] [Full Text] [PDF]  

Sarah Melissa P. Jacobo, Marcy L. Guerra, Rachel E. Jarrard, Julie A. Przybyla, Guohong Liu, Val J. Watts, and Gregory H. Hockerman

The Intracellular II-III Loops of Ca_v1.2 and Ca_v1.3 Uncouple L-Type Voltage-Gated Ca²⁺ Channels from Glucagon-Like Peptide-1 Potentiation of Insulin Secretion in INS-1 Cells via Displacement from Lipid Rafts
J Pharmacol Exp Ther 2009 330: 283-293. Published online April 7, 2009; 10.1124/jpet.109.150672 [Abstract] [Full Text] [PDF] [Data Supplement]   

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

James R. Roede, David J. Orlicky, Aron B. Fisher, and Dennis R. Petersen

Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation
J Pharmacol Exp Ther 2009 330: 79-88. Published online April 22, 2009; 10.1124/jpet.109.152983 [Abstract] [Full Text] [PDF]  

Sun Jung Myung, Jung-Hwan Yoon, Bo Hyun Kim, Jeong-Hoon Lee, Eun Uk Jung, and Hyo-Suk Lee

Heat Shock Protein 90 Inhibitor Induces Apoptosis and Attenuates Activation of Hepatic Stellate Cells
J Pharmacol Exp Ther 2009 330: 276-282. Published online March 27, 2009; 10.1124/jpet.109.151860 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Hideo Kohka Takahashi, Shuji Mori, Hidenori Wake, Keyue Liu, Tadashi Yoshino, Katsuhisa Ohashi, Noriaki Tanaka, Kenichi Shikata, Hirofumi Makino, and Masahiro Nishibori

Advanced Glycation End Products Subspecies-Selectively Induce Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells
J Pharmacol Exp Ther 2009 330: 89-98. Published online April 20, 2009; 10.1124/jpet.109.150581 [Abstract] [Full Text] [PDF]  

A. Nadeem, D. S. Ponnoth, H. R. Ansari, T. P. Batchelor, R. D. Dey, C. Ledent, and S. J. Mustafa

A_2A Adenosine Receptor Deficiency Leads to Impaired Tracheal Relaxation via NADPH Oxidase Pathway in Allergic Mice
J Pharmacol Exp Ther 2009 330: 99-108. Published online April 24, 2009; 10.1124/jpet.109.151613 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Xi Yang, Shun-Hsin Liang, Denise M. Weyant, Philip Lazarus, Carla J. Gallagher, and Curtis J. Omiecinski

The Expression of Human Microsomal Epoxide Hydrolase Is Predominantly Driven by a Genetically Polymorphic Far Upstream Promoter
J Pharmacol Exp Ther 2009 330: 23-30. Published online April 13, 2009; 10.1124/jpet.109.150870 [Abstract] [Full Text] [PDF]  

Haodan Yuan, Bo Feng, Ying Yu, Jonathan Chupka, Jenny Y. Zheng, Timothy G. Heath, and Brian R. Bond

Renal Organic Anion Transporter-Mediated Drug-Drug Interaction between Gemcabene and Quinapril
J Pharmacol Exp Ther 2009 330: 191-197. Published online April 6, 2009; 10.1124/jpet.108.149476 [Abstract] [Full Text] [PDF]  

Feng Zhu, LianYi Han, ChanJuan Zheng, Bin Xie, Martti T. Tammi, ShengYong Yang, YuQuan Wei, and YuZong Chen

What Are Next Generation Innovative Therapeutic Targets? Clues from Genetic, Structural, Physicochemical, and Systems Profiles of Successful Targets
J Pharmacol Exp Ther 2009 330: 304-315. Published online April 8, 2009; 10.1124/jpet.108.149955 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

Noriko Narimatsu, Naoaki Harada, Hiroki Kurihara, Naomi Nakagata, Kazuya Sobue, and Kenji Okajima

Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus
J Pharmacol Exp Ther 2009 330: 2-12. Published online March 24, 2009; 10.1124/jpet.108.147280 [Abstract] [Full Text] [PDF]  

Yuko Nonaka, Akihiro Koumura, Kana Hyakkoku, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, and Hideaki Hara

Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone
J Pharmacol Exp Ther 2009 330: 13-22. Published online March 31, 2009; 10.1124/jpet.109.151548 [Abstract] [Full Text] [PDF] [Data Supplement]   

Dustin K. Williams, Clare Stokes, Nicole A. Horenstein, and Roger L. Papke

Differential Regulation of Receptor Activation and Agonist Selectivity by Highly Conserved Tryptophans in the Nicotinic Acetylcholine Receptor Binding Site
J Pharmacol Exp Ther 2009 330: 40-53. Published online April 1, 2009; 10.1124/jpet.109.151225 [Abstract] [Full Text] [PDF]  

Christine Dugovic, Jonathan E. Shelton, Leah E. Aluisio, Ian C. Fraser, Xiaohui Jiang, Steven W. Sutton, Pascal Bonaventure, Sujin Yun, Xiaorong Li, Brian Lord, Curt A. Dvorak, Nicholas I. Carruthers, and Timothy W. Lovenberg

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
J Pharmacol Exp Ther 2009 330: 142-151. Published online April 10, 2009; 10.1124/jpet.109.152009 [Abstract] [Full Text] [PDF]  

K. J. Jackson and M. I. Damaj

L-Type Calcium Channels and Calcium/Calmodulin-Dependent Kinase II Differentially Mediate Behaviors Associated with Nicotine Withdrawal in Mice
J Pharmacol Exp Ther 2009 330: 152-161. Published online March 31, 2009; 10.1124/jpet.109.151530 [Abstract] [Full Text] [PDF]  

Akio Satow, Gentaroh Suzuki, Shunsuke Maehara, Hirohiko Hikichi, Takeshi Murai, Takashi Murai, Hiroko Kawagoe-Takaki, Mikiko Hata, Satoru Ito, Satoshi Ozaki, Hiroshi Kawamoto, and Hisashi Ohta

Unique Antipsychotic Activities of the Selective Metabotropic Glutamate Receptor 1 Allosteric Antagonist 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
J Pharmacol Exp Ther 2009 330: 179-190. Published online April 9, 2009; 10.1124/jpet.109.151118 [Abstract] [Full Text] [PDF] [Data Supplement]   

Brian T. Welsh, Beth E. Goldstein, and S. John Mihic

Single-Channel Analysis of Ethanol Enhancement of Glycine Receptor Function
J Pharmacol Exp Ther 2009 330: 198-205. Published online April 20, 2009; 10.1124/jpet.109.154344 [Abstract] [Full Text] [PDF]  

Silja Horak, Alexandra Koschak, Hermann Stuppner, and Jörg Striessnig

Use-Dependent Block of Voltage-Gated Ca_v2.1 Ca²⁺ Channels by Petasins and Eudesmol Isomers
J Pharmacol Exp Ther 2009 330: 220-226. Published online April 15, 2009; 10.1124/jpet.109.151183 [Abstract] [Full Text] [PDF]  

Daniella Rylander, Alessandra Recchia, Flora Mela, Andrzej Dekundy, Wojciech Danysz, and M. Angela Cenci

Pharmacological Modulation of Glutamate Transmission in a Rat Model of L-DOPA-Induced Dyskinesia: Effects on Motor Behavior and Striatal Nuclear Signaling
J Pharmacol Exp Ther 2009 330: 227-235. Published online April 8, 2009; 10.1124/jpet.108.150425 [Abstract] [Full Text] [PDF] [Data Supplement]   

Katherine L. Nicholson, Robert L. Balster, Krystyna Golembiowska, Magdalena Kowalska, Joseph P. Tizzano, Phil Skolnick, and Anthony S. Basile

Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine
J Pharmacol Exp Ther 2009 330: 236-248. Published online April 8, 2009; 10.1124/jpet.109.150540 [Abstract] [Full Text] [PDF]  

John Malysz, Jens Halvard Grønlien, David J. Anderson, Monika Håkerud, Kirsten Thorin-Hagene, Hilde Ween, Caroline Wetterstrand, Clark A. Briggs, Ramin Faghih, William H. Bunnelle, and Murali Gopalakrishnan

In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of 7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile
J Pharmacol Exp Ther 2009 330: 257-267. Published online April 23, 2009; 10.1124/jpet.109.151886 [Abstract] [Full Text] [PDF]  

Jay J. Liu, Kemal Payza, Jian Huang, Ruifeng Liu, Tongming Chen, Martin Coupal, Jennifer M. A. Laird, Chang-Qing Cao, Joanne Butterworth, Stéphanie Lapointe, Malken Bayrakdarian, Shephali Trivedi, and J. Robert Bostwick

Discovery and Pharmacological Characterization of a Small-Molecule Antagonist at Neuromedin U Receptor NMUR2
J Pharmacol Exp Ther 2009 330: 268-275. Published online April 15, 2009; 10.1124/jpet.109.152967 [Abstract] [Full Text] [PDF] [Data Supplement]   

Robert A. Hodgson, Rosalia Bertorelli, Geoffrey B. Varty, Jean E. Lachowicz, Angelo Forlani, Silva Fredduzzi, Mary E. Cohen-Williams, Guy A. Higgins, Francesco Impagnatiello, Elisa Nicolussi, Leonard E. Parra, Carolyn Foster, Ying Zhai, Bernie R. Neustadt, Andrew W. Stamford, Eric M. Parker, Angelo Reggiani, and John C. Hunter

Characterization of the Potent and Highly Selective A_2A Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models of Movement Disorders and Depression
J Pharmacol Exp Ther 2009 330: 294-303. Published online March 30, 2009; 10.1124/jpet.108.149617 [Abstract] [Full Text] [PDF]  

Donna L. Maier, Cindy Sobotka-Briner, Min Ding, Mark E. Powell, Qiaoling Jiang, Geraldine Hill, J. Richard Heys, Charles S. Elmore, M. Edward Pierson, and Ladislav Mrzljak

[N-methyl-³H₃]AZ10419369 Binding to the 5-HT_1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy
J Pharmacol Exp Ther 2009 330: 342-351. Published online April 28, 2009; 10.1124/jpet.109.150722 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Patrick J. Shaw, Patricia E. Ganey, and Robert A. Roth

Trovafloxacin Enhances the Inflammatory Response to a Gram-Negative or a Gram-Positive Bacterial Stimulus, Resulting in Neutrophil-Dependent Liver Injury in Mice
J Pharmacol Exp Ther 2009 330: 72-78. Published online April 7, 2009; 10.1124/jpet.109.151068 [Abstract] [Full Text] [PDF]  

Julie A. Coffield and Xiuzhen Yan

Neuritogenic Actions of Botulinum Neurotoxin A on Cultured Motor Neurons
J Pharmacol Exp Ther 2009 330: 352-358. Published online April 16, 2009; 10.1124/jpet.108.147744 [Abstract] [Full Text] [PDF]  

ERRATUM:

Correction to "Nonpeptidic Allosteric Antagonists Differentially Bind to the CXCR2 Chemokine Receptor"
J Pharmacol Exp Ther 2009 330: 367. [Full Text] [PDF]  

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