JPET -- Table of Contents (327 [1])

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October 2008; 327 (1)   [Index by Author] [Cover Caption]

       BEHAVIORAL PHARMACOLOGY

       CARDIOVASCULAR

       CELLULAR AND MOLECULAR

       ENDOCRINE AND DIABETES

       GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

       INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

       METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

       NEUROPHARMACOLOGY

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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BEHAVIORAL PHARMACOLOGY:

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, and Toshitaka Nabeshima: The Extensive Nitration of Neurofilament Light Chain in the Hippocampus Is Associated with the Cognitive Impairment Induced by Amyloid β in Mice
J Pharmacol Exp Ther 2008 327: 137-147. Published online July 11, 2008; 10.1124/jpet.108.141309 [Abstract] [Full Text] [PDF]

Tanuja Bordia, Carla Campos, Luping Huang, and Maryka Quik: Continuous and Intermittent Nicotine Treatment Reduces L-3,4-Dihydroxyphenylalanine (L-DOPA)-Induced Dyskinesias in a Rat Model of Parkinson's Disease
J Pharmacol Exp Ther 2008 327: 239-247. Published online July 23, 2008; 10.1124/jpet.108.140897 [Abstract] [Full Text] [PDF]

Anni-Maija Linden, M. Isabel Aller, Elli Leppä, Per H. Rosenberg, William Wisden, and Esa R. Korpi: K⁺ Channel TASK-1 Knockout Mice Show Enhanced Sensitivities to Ataxic and Hypnotic Effects of GABA_A Receptor Ligands
J Pharmacol Exp Ther 2008 327: 277-286. Published online July 25, 2008; 10.1124/jpet.108.142083 [Abstract] [Full Text] [PDF]

CARDIOVASCULAR:

Salvatore Cuzzocrea, Rosanna Di Paola, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Placido Bramanti, and Daniela Salvemini: Anti-Inflammatory and Anti-Apoptotic Effects of Fumonisin B1, an Inhibitor of Ceramide Synthase, in a Rodent Model of Splanchnic Ischemia and Reperfusion Injury
J Pharmacol Exp Ther 2008 327: 45-57. Published online July 8, 2008; 10.1124/jpet.108.139808 [Abstract] [Full Text] [PDF]

Pei-Suen Tsou, Vamsi Addanki, and Ho-Leung Fung: Dissociation between Superoxide Accumulation and Nitroglycerin-Induced Tolerance
J Pharmacol Exp Ther 2008 327: 97-104. Published online July 24, 2008; 10.1124/jpet.108.138784 [Abstract] [Full Text] [PDF]

Seta Stanbouly, Lorrie A. Kirshenbaum, Douglas L. Jones, and Morris Karmazyn: Sodium Hydrogen Exchange 1 (NHE-1) Regulates Connexin 43 Expression in Cardiomyocytes via Reverse Mode Sodium Calcium Exchange and c-Jun NH₂-Terminal Kinase-Dependent Pathways
J Pharmacol Exp Ther 2008 327: 105-113. Published online July 23, 2008; 10.1124/jpet.108.140228 [Abstract] [Full Text] [PDF]

Taeko Matsuda, Yumiko Toyohira, Susumu Ueno, Masato Tsutsui, and Nobuyuki Yanagihara: Simvastatin Inhibits Catecholamine Secretion and Synthesis Induced by Acetylcholine via Blocking Na⁺ and Ca²⁺ Influx in Bovine Adrenal Medullary Cells
J Pharmacol Exp Ther 2008 327: 130-136. Published online July 1, 2008; 10.1124/jpet.108.139659 [Abstract] [Full Text] [PDF]

Eva H. C. Tang and Paul M. Vanhoutte: Gap Junction Inhibitors Reduce Endothelium-Dependent Contractions in the Aorta of Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2008 327: 148-153. Published online July 16, 2008; 10.1124/jpet.108.140046 [Abstract] [Full Text] [PDF]

CELLULAR AND MOLECULAR:

Austin M. Guo, Ju Sheng, Gloria M. Scicli, Ali S. Arbab, Norman L. Lehman, Paul A. Edwards, John R. Falck, Richard J. Roman, and A. Guillermo Scicli: Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo
J Pharmacol Exp Ther 2008 327: 10-19. Published online June 30, 2008; 10.1124/jpet.108.140889 [Abstract] [Full Text] [PDF]

Lihua Jin, Maki Miyazaki, Satomi Mizuno, Miki Takigawa, Tadao Hirose, Kazuhiro Nishimura, Toshihiko Toida, Keith Williams, Keiko Kashiwagi, and Kazuei Igarashi: The Pore Region of N-Methyl-D-aspartate Receptors Differentially Influences Stimulation and Block by Spermine
J Pharmacol Exp Ther 2008 327: 68-77. Published online July 16, 2008; 10.1124/jpet.108.140459 [Abstract] [Full Text] [PDF]

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch, and Rob Leurs: Phenylalanine 169 in the Second Extracellular Loop of the Human Histamine H₄ Receptor Is Responsible for the Difference in Agonist Binding between Human and Mouse H₄ Receptors
J Pharmacol Exp Ther 2008 327: 88-96. Published online July 17, 2008; 10.1124/jpet.108.140343 [Abstract] [Full Text] [PDF] [Data Supplement]

Haoyu Zeng, Earl Gordon, Zuojun Lin, Irina M. Lozinskaya, Robert N. Willette, and Xiaoping Xu: 1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a Potent and Highly Selective Small Molecule Blocker of the Large-Conductance Voltage-Gated and Calcium-Dependent K⁺ Channel
J Pharmacol Exp Ther 2008 327: 168-177. Published online June 30, 2008; 10.1124/jpet.108.139733 [Abstract] [Full Text] [PDF]

Frédéric Chappe, Matthew E. Loewen, John W. Hanrahan, and Valérie Chappe: Vasoactive Intestinal Peptide Increases Cystic Fibrosis Transmembrane Conductance Regulator Levels in the Apical Membrane of Calu-3 Cells through a Protein Kinase C-Dependent Mechanism
J Pharmacol Exp Ther 2008 327: 226-238. Published online July 23, 2008; 10.1124/jpet.108.141143 [Abstract] [Full Text] [PDF]

ENDOCRINE AND DIABETES:

Alexander de Giorgio-Miller, Peter Bungay, Michelle Tutt, Julie Owen, David Goodwin, and Nick Pullen: The Translational Pharmacology of a Novel, Potent, and Selective Nonsteroidal Progesterone Receptor Antagonist, 2-[4-(4-Cyano-phenoxy)-3,5-dicyclopropyl-1H-pyrazol-1-yl]-N-methylacetamide (PF-02367982)
J Pharmacol Exp Ther 2008 327: 78-87. Published online July 1, 2008; 10.1124/jpet.108.140467 [Abstract] [Full Text] [PDF] [Data Supplement]

Yoshikazu Fujimori, Kenji Katsuno, Ikumi Nakashima, Yukiko Ishikawa-Takemura, Hideki Fujikura, and Masayuki Isaji: Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models
J Pharmacol Exp Ther 2008 327: 268-276. Published online June 26, 2008; 10.1124/jpet.108.140210 [Abstract] [Full Text] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F. Brading: Levcromakalim and MgGDP Activate Small Conductance ATP-Sensitive K⁺ Channels of K⁺ Channel Pore 6.1/Sulfonylurea Receptor 2A in Pig Detrusor Smooth Muscle Cells: Uncoupling of cAMP Signal Pathways
J Pharmacol Exp Ther 2008 327: 114-123. Published online July 2, 2008; 10.1124/jpet.108.140269 [Abstract] [Full Text] [PDF]

Stephen M. Sims, Tom Chrones, and Harold G. Preiksaitis: Calcium Sensitization in Human Esophageal Muscle: Role for RhoA Kinase in Maintenance of Lower Esophageal Sphincter Tone
J Pharmacol Exp Ther 2008 327: 178-186. Published online July 15, 2008; 10.1124/jpet.108.140806 [Abstract] [Full Text] [PDF]

Le Yu, William Ka Kei Wu, Zhi Jie Li, Helen Pui Shan Wong, Emily Kin Ki Tai, Hai Tao Li, Ya Chun Wu, and Chi Hin Cho: E Series of Prostaglandin Receptor 2-Mediated Activation of Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Is Required for the Mitogenic Action of Prostaglandin E₂ in Esophageal Squamous-Cell Carcinoma
J Pharmacol Exp Ther 2008 327: 258-267. Published online June 26, 2008; 10.1124/jpet.108.141275 [Abstract] [Full Text] [PDF] [Data Supplement]

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Mieke Buntinx, Bart Hermans, Jan Goossens, Dieder Moechars, Ron A. H. J. Gilissen, Julien Doyon, Staf Boeckx, Erwin Coesemans, Guy Van Lommen, and Jean P. Van Wauwe: Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
J Pharmacol Exp Ther 2008 327: 1-9. Published online July 3, 2008; 10.1124/jpet.108.140723 [Abstract] [Full Text] [PDF] [Data Supplement]

Emrah Yatkin, Jenni Bernoulli, Risto Lammintausta, and Risto Santti: Fispemifene [Z-2-{2-[4-(4-Chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol], a Novel Selective Estrogen Receptor Modulator, Attenuates Glandular Inflammation in an Animal Model of Chronic Nonbacterial Prostatitis
J Pharmacol Exp Ther 2008 327: 58-67. Published online June 26, 2008; 10.1124/jpet.108.139501 [Abstract] [Full Text] [PDF]

Luciana Pontes Coelho, Magda Fráguas Serra, Ana Lúcia de Aguiar Pires, Renato Sérgio Balão Cordeiro, Patrícia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, and Marco Aurélio Martins: 7-Epiclusianone, a Tetraprenylated Benzophenone, Relaxes Airway Smooth Muscle through Activation of the Nitric Oxide-cGMP Pathway
J Pharmacol Exp Ther 2008 327: 206-214. Published online June 30, 2008; 10.1124/jpet.108.138032 [Abstract] [Full Text] [PDF]

Consuelo Amantini, Michela Mosca, Roberta Lucciarini, Marina Cecilia Perfumi, and Giorgio Santoni: Thiorphan-Induced Survival and Proliferation of Rat Thymocytes by Activation of Akt/Survivin Pathway and Inhibition of Caspase-3 Activity
J Pharmacol Exp Ther 2008 327: 215-225. Published online July 11, 2008; 10.1124/jpet.108.138719 [Abstract] [Full Text] [PDF]

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Mustafa Vali, Josephina A. Vossen, Manon Buijs, James M. Engles, Eleni Liapi, Veronica Prieto Ventura, Afsheen Khwaja, Obele Acha-Ngwodo, Ganapathy Shanmugasundaram, Labiq Syed, Richard L. Wahl, and Jean-Francois H. Geschwind: Targeting of VX2 Rabbit Liver Tumor by Selective Delivery of 3-Bromopyruvate: A Biodistribution and Survival Study
J Pharmacol Exp Ther 2008 327: 32-37. Published online June 30, 2008; 10.1124/jpet.108.141093 [Abstract] [Full Text] [PDF]

Melanie Mueller, Frank T. Peters, Hans H. Maurer, Una D. McCann, and George A. Ricaurte: Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses
J Pharmacol Exp Ther 2008 327: 38-44. Published online June 30, 2008; 10.1124/jpet.108.141366 [Abstract] [Full Text] [PDF]

Jennifer B. Dennison, Michael A. Mohutsky, Robert J. Barbuch, Steven A. Wrighton, and Stephen D. Hall: Apparent High CYP3A5 Expression Is Required for Significant Metabolism of Vincristine by Human Cryopreserved Hepatocytes
J Pharmacol Exp Ther 2008 327: 248-257. Published online July 23, 2008; 10.1124/jpet.108.139998 [Abstract] [Full Text] [PDF]

NEUROPHARMACOLOGY:

M. A. Starr, M. E. Page, and B. D. Waterhouse: MDMA (3,4-Methylenedioxymethamphetamine)-Mediated Distortion of Somatosensory Signal Transmission and Neurotransmitter Efflux in the Ventral Posterior Medial Thalamus
J Pharmacol Exp Ther 2008 327: 20-31. Published online July 7, 2008; 10.1124/jpet.108.139337 [Abstract] [Full Text] [PDF]

Kathryn T. O'Leary, Neeraja Parameswaran, Louisa C. Johnston, J. Michael McIntosh, Donato A. Di Monte, and Maryka Quik: Paraquat Exposure Reduces Nicotinic Receptor-Evoked Dopamine Release in Monkey Striatum
J Pharmacol Exp Ther 2008 327: 124-129. Published online July 7, 2008; 10.1124/jpet.108.141861 [Abstract] [Full Text] [PDF]

Eduardo R. Butelman, Szymon Rus, Denise S. Simpson, Angela Wolf, Thomas E. Prisinzano, and Mary Jeanne Kreek: The Effects of Herkinorin, the First µ-Selective Ligand from a Salvinorin A-Derived Scaffold, in a Neuroendocrine Biomarker Assay in Nonhuman Primates
J Pharmacol Exp Ther 2008 327: 154-160. Published online July 1, 2008; 10.1124/jpet.108.140079 [Abstract] [Full Text] [PDF]

Trent J. Volz, Sarah J. Farnsworth, Shane D. Rowley, Glen R. Hanson, and Annette E. Fleckenstein: Methylphenidate-Induced Increases in Vesicular Dopamine Sequestration and Dopamine Release in the Striatum: The Role of Muscarinic and Dopamine D2 Receptors
J Pharmacol Exp Ther 2008 327: 161-167. Published online June 30, 2008; 10.1124/jpet.108.139386 [Abstract] [Full Text] [PDF]

Yun Liu and Rae R. Matsumoto: Alterations in Fos-Related Antigen 2 and ${sigma}$ ₁ Receptor Gene and Protein Expression Are Associated with the Development of Cocaine-Induced Behavioral Sensitization: Time Course and Regional Distribution Studies
J Pharmacol Exp Ther 2008 327: 187-195. Published online June 30, 2008; 10.1124/jpet.108.141051 [Abstract] [Full Text] [PDF]

Cheng Xiao, Chunyi Zhou, Kaixun Li, Daryl L. Davies, and Jiang H. Ye: Purinergic Type 2 Receptors at GABAergic Synapses on Ventral Tegmental Area Dopamine Neurons Are Targets for Ethanol Action
J Pharmacol Exp Ther 2008 327: 196-205. Published online June 26, 2008; 10.1124/jpet.108.139766 [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Cover Caption:

About the cover: Close-up of the EL2 as observed in the recent X-ray structure of the β₂-adrenergic receptor (Cherezov et al., 2007) (A) and homology model of the human H₄R (B). See the article by Lim et al. on page 88 of this issue.