HIGHLIGHTED PAPERS:

CENTENNIAL PERSPECTIVE:

Connie Cheung and Frank J. Gonzalez

Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment
J Pharmacol Exp Ther 2008 327: 288-299. Published online August 5, 2008; 10.1124/jpet.108.141242 [Abstract] [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

Man Jiang and Zheng Dong

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity
J Pharmacol Exp Ther 2008 327: 300-307. Published online August 5, 2008; 10.1124/jpet.108.139162 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Maria Scherma, Leigh V. Panlilio, Paola Fadda, Liana Fattore, Islam Gamaleddin, Bernard Le Foll, Zuzana Justinová, Eva Mikics, Jozsef Haller, Julie Medalie, Jessica Stroik, Chanel Barnes, Sevil Yasar, Gianluigi Tanda, Daniele Piomelli, Walter Fratta, and Steven R. Goldberg

Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats
J Pharmacol Exp Ther 2008 327: 482-490. Published online August 25, 2008; 10.1124/jpet.108.142224 [Abstract] [Full Text] [PDF]  

Elizabeth J. Rahn, Alexander M. Zvonok, Ganesh A. Thakur, Atmaram D. Khanolkar, Alexandros Makriyannis, and Andrea G. Hohmann

Selective Activation of Cannabinoid CB₂ Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
J Pharmacol Exp Ther 2008 327: 584-591. Published online July 29, 2008; 10.1124/jpet.108.141994 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Volker Rudolph, Tanja K. Rudolph, Francisco J. Schopfer, Gustavo Bonacci, Denise Lau, Katalin Szöcs, Anna Klinke, Thomas Meinertz, Bruce A. Freeman, and Stephan Baldus

Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase
J Pharmacol Exp Ther 2008 327: 324-331. Published online August 13, 2008; 10.1124/jpet.108.142414 [Abstract] [Full Text] [PDF] [Data Supplement]   

Dacheng Peng, Richard A. Hiipakka, Qing Dai, Jian Guo, Catherine A. Reardon, Godfrey S. Getz, and Shutsung Liao

Antiatherosclerotic Effects of a Novel Synthetic Tissue-Selective Steroidal Liver X Receptor Agonist in Low-Density Lipoprotein Receptor-Deficient Mice
J Pharmacol Exp Ther 2008 327: 332-342. Published online August 22, 2008; 10.1124/jpet.108.142687 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lubo Zhang, DaLiao Xiao, and Xiangqun Hu

Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep
J Pharmacol Exp Ther 2008 327: 425-431. Published online August 5, 2008; 10.1124/jpet.108.141283 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Eric G. Stefanich, Song Ren, Dimitry M. Danilenko, Amy Lim, An Song, Suhasini Iyer, and Paul J. Fielder

Evidence for an Asialoglycoprotein Receptor on Nonparenchymal Cells for O-Linked Glycoproteins
J Pharmacol Exp Ther 2008 327: 308-315. Published online August 26, 2008; 10.1124/jpet.108.142232 [Abstract] [Full Text] [PDF]  

Rachel L. Thomas, Rajendra Mistry, Christopher J. Langmead, Martyn D. Wood, and R. A. John Challiss

G Protein Coupling and Signaling Pathway Activation by M₁ Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists
J Pharmacol Exp Ther 2008 327: 365-374. Published online July 29, 2008; 10.1124/jpet.108.141788 [Abstract] [Full Text] [PDF]  

Hinako Suga, Katherine W. Figueroa, and Frederick J. Ehlert

Use of Acetylcholine Mustard to Study Allosteric Interactions at the M₂ Muscarinic Receptor
J Pharmacol Exp Ther 2008 327: 518-528. Published online August 5, 2008; 10.1124/jpet.108.141234 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Cara A. Rabik, Melissa L. Fishel, Julianne L. Holleran, Kristen Kasza, Mark R. Kelley, Merrill J. Egorin, and M. Eileen Dolan

Enhancement of Cisplatin [cis-Diammine Dichloroplatinum (II)] Cytotoxicity by O⁶-Benzylguanine Involves Endoplasmic Reticulum Stress
J Pharmacol Exp Ther 2008 327: 442-452. Published online July 29, 2008; 10.1124/jpet.108.141291 [Abstract] [Full Text] [PDF] [Data Supplement]   

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Dinesh Thapa, Jong Suk Lee, Su-Young Park, Yun-Hee Bae, Soo-Kyung Bae, Jun Bum Kwon, Kyoung-Jin Kim, Mi-Kyoung Kwak, Young-Joon Park, Han Gon Choi, and Jung-Ae Kim

Clotrimazole Ameliorates Intestinal Inflammation and Abnormal Angiogenesis by Inhibiting Interleukin-8 Expression through a Nuclear Factor-B-Dependent Manner
J Pharmacol Exp Ther 2008 327: 353-364. Published online August 26, 2008; 10.1124/jpet.108.141887 [Abstract] [Full Text] [PDF]  

Jeremy Mark Hernandez, Gerard Cox, and Luke Jeffrey Janssen

Involvement of the Neurokinin-2 Receptor in Airway Smooth Muscle Stretch-Activated Contractions Assessed in Perfused Intact Bovine Bronchial Segments
J Pharmacol Exp Ther 2008 327: 503-510. Published online August 21, 2008; 10.1124/jpet.108.141176 [Abstract] [Full Text] [PDF]  

Gracious R. Ross, Bichoy H. Gabra, William L. Dewey, and Hamid I. Akbarali

Morphine Tolerance in the Mouse Ileum and Colon
J Pharmacol Exp Ther 2008 327: 561-572. Published online August 5, 2008; 10.1124/jpet.108.143438 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Byung Hak Kim, Seong Su Hong, Soon Woo Kwon, Hwa Young Lee, Hyeran Sung, In-Jeong Lee, Bang Yeon Hwang, Sukgil Song, Chong-Kil Lee, Daehyun Chung, Byeongwoo Ahn, Sang-Yoon Nam, Sang-Bae Han, and Youngsoo Kim

Diarctigenin, a Lignan Constituent from Arctium lappa, Down-Regulated Zymosan-Induced Transcription of Inflammatory Genes through Suppression of DNA Binding Ability of Nuclear Factor-B in Macrophages
J Pharmacol Exp Ther 2008 327: 393-401. Published online August 11, 2008; 10.1124/jpet.108.140145 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G. Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H. H. Neubert, Hannelore Daniel, and Matthias Brandsch

Transport of Angiotensin-Converting Enzyme Inhibitors by H⁺/Peptide Transporters Revisited
J Pharmacol Exp Ther 2008 327: 432-441. Published online August 19, 2008; 10.1124/jpet.108.143339 [Abstract] [Full Text] [PDF]  

Yoshiaki Kitamura, Masakazu Hirouchi, Hiroyuki Kusuhara, John D. Schuetz, and Yuichi Sugiyama

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)
J Pharmacol Exp Ther 2008 327: 465-473. Published online August 21, 2008; 10.1124/jpet.108.140475 [Abstract] [Full Text] [PDF]  

Ziping Yang, Daniel Wu, Tot Bui, and Rodney J. Y. Ho

A Novel Human Multidrug Resistance Gene MDR1 Variant G571A (G191R) Modulates Cancer Drug Resistance and Efflux Transport
J Pharmacol Exp Ther 2008 327: 474-481. Published online August 22, 2008; 10.1124/jpet.108.138313 [Abstract] [Full Text] [PDF]  

Donelly A. van Schalkwyk, Waldemar Priebe, and Kevin J. Saliba

The Inhibitory Effect of 2-Halo Derivatives of D-Glucose on Glycolysis and on the Proliferation of the Human Malaria Parasite Plasmodium falciparum
J Pharmacol Exp Ther 2008 327: 511-517. Published online August 19, 2008; 10.1124/jpet.108.141929 [Abstract] [Full Text] [PDF]  

Natasha T. Snider, Matthew J. Sikora, Chitra Sridar, Thomas J. Feuerstein, James M. Rae, and Paul F. Hollenberg

The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6
J Pharmacol Exp Ther 2008 327: 538-545. Published online August 12, 2008; 10.1124/jpet.108.141796 [Abstract] [Full Text] [PDF]  

Tomoe Fujita, Shuichi Yasuda, Yuji Kamata, Kazumi Fujita, Yoshio Ohtani, Yuji Kumagai, and Masataka Majima

Contribution of Down-Regulation of Intestinal and Hepatic Cytochrome P450 3A to Increased Absorption of Cyclosporine A in a Rat Nephrosis Model
J Pharmacol Exp Ther 2008 327: 592-599. Published online August 25, 2008; 10.1124/jpet.108.142091 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Volker Nimmrich, Robert Szabo, Csaba Nyakas, Ivica Granic, Klaus G. Reymann, Ulrich H. Schröder, Gerhard Gross, Hans Schoemaker, Karsten Wicke, Achim Möller, and Paul Luiten

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
J Pharmacol Exp Ther 2008 327: 343-352. Published online August 13, 2008; 10.1124/jpet.108.142679 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, and Hui-Lin Pan

Sustained Inhibition of Neurotransmitter Release from Nontransient Receptor Potential Vanilloid Type 1-Expressing Primary Afferents by µ-Opioid Receptor Activation-Enkephalin in the Spinal Cord
J Pharmacol Exp Ther 2008 327: 375-382. Published online July 31, 2008; 10.1124/jpet.108.141226 [Abstract] [Full Text] [PDF]  

Dorothee Abramowski, Karl-Heinz Wiederhold, Ulrich Furrer, Anne-Lise Jaton, Anton Neuenschwander, Marie-Josephine Runser, Simone Danner, Julia Reichwald, Domenico Ammaturo, Dieter Staab, Markus Stoeckli, Heinrich Rueeger, Ulf Neumann, and Matthias Staufenbiel

Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following -Secretase Inhibition
J Pharmacol Exp Ther 2008 327: 411-424. Published online August 7, 2008; 10.1124/jpet.108.140327 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yelenis Herrera, Christopher Katnik, Jael D. Rodriguez, Aaron A. Hall, Alison Willing, Keith R. Pennypacker, and Javier Cuevas

-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca²⁺ Influx in Rat Cortical Neurons
J Pharmacol Exp Ther 2008 327: 491-502. Published online August 22, 2008; 10.1124/jpet.108.143974 [Abstract] [Full Text] [PDF]  

Neal Innocent, Phil D. Livingstone, Arik Hone, Atsuko Kimura, Tracey Young, Paul Whiteaker, J. Michael McIntosh, and Susan Wonnacott

Conotoxin Arenatus IB[V11L,V16D] Is a Potent and Selective Antagonist at Rat and Human Native 7 Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2008 327: 529-537. Published online July 29, 2008; 10.1124/jpet.108.142943 [Abstract] [Full Text] [PDF] [Erratum]   

James J. Burston, Laura J. Sim-Selley, John P. Harloe, Anu Mahadevan, Raj K. Razdan, Dana E. Selley, and Jenny L. Wiley

N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase
J Pharmacol Exp Ther 2008 327: 546-553. Published online August 5, 2008; 10.1124/jpet.108.141382 [Abstract] [Full Text] [PDF]  

Michael R. Tilley and Howard H. Gu

The Effects of Methylphenidate on Knockin Mice with a Methylphenidate-Resistant Dopamine Transporter
J Pharmacol Exp Ther 2008 327: 554-560. Published online August 12, 2008; 10.1124/jpet.108.141713 [Abstract] [Full Text] [PDF]  

Yanqi Liang, Amanda M. Shaw, Mona Boules, Siobhan Briody, Jessica Robinson, Alfredo Oliveros, Eric Blazar, Katrina Williams, Yiqun Zhang, Paul R. Carlier, and Elliott Richelson

Antidepressant-Like Pharmacological Profile of a Novel Triple Reuptake Inhibitor, (1S,2S)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)
J Pharmacol Exp Ther 2008 327: 573-583. Published online August 8, 2008; 10.1124/jpet.108.143610 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tadakatsu Matsuno, Yasushi Ito, Takamasa Ohashi, Masahiro Morise, Naoya Takeda, Kaoru Shimokata, Kazuyoshi Imaizumi, Hiroaki Kume, and Yoshinori Hasegawa

Dual Pathway Activated by tert-Butyl Hydroperoxide in Human Airway Anion Secretion
J Pharmacol Exp Ther 2008 327: 453-464. Published online July 29, 2008; 10.1124/jpet.108.141580 [Abstract] [Full Text] [PDF]  

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