PERSPECTIVES IN PHARMACOLOGY:

Jie Liu, Yuanfu Lu, Qin Wu, Robert A. Goyer, and Michael P. Waalkes

Mineral Arsenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite
J Pharmacol Exp Ther 2008 326: 363-368. Published online May 7, 2008; 10.1124/jpet.108.139543 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Thierry Bordet, Bruno Buisson, Magali Michaud, Jean-Louis Abitbol, Fabien Marchand, John Grist, Emile Andriambeloson, Marzia Malcangio, and Rebecca M. Pruss

Specific Antinociceptive Activity of Cholest-4-en-3-one, Oxime (TRO19622) in Experimental Models of Painful Diabetic and Chemotherapy-Induced Neuropathy
J Pharmacol Exp Ther 2008 326: 623-632. Published online May 20, 2008; 10.1124/jpet.108.139410 [Abstract] [Full Text] [PDF] [Data Supplement]   

Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Koki Kifune, and Toshihiro Dohi

Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice
J Pharmacol Exp Ther 2008 326: 633-645. Published online April 30, 2008; 10.1124/jpet.108.136267 [Abstract] [Full Text] [PDF]  

Geoffrey B. Varty, Sherry X. Lu, Cynthia A. Morgan, Mary E. Cohen-Williams, Robert A. Hodgson, April Smith-Torhan, Hongtao Zhang, Ahmad B. Fawzi, Michael P. Graziano, Ginny D. Ho, Julius Matasi, Deen Tulshian, Vicki L. Coffin, and Galen J. Carey

The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
J Pharmacol Exp Ther 2008 326: 672-682. Published online May 20, 2008; 10.1124/jpet.108.136937 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Takahiro Nagayama, Manling Zhang, Steven Hsu, Eiki Takimoto, and David A. Kass

Sustained Soluble Guanylate Cyclase Stimulation Offsets Nitric-Oxide Synthase Inhibition to Restore Acute Cardiac Modulation by Sildenafil
J Pharmacol Exp Ther 2008 326: 380-387. Published online May 2, 2008; 10.1124/jpet.108.137422 [Abstract] [Full Text] [PDF] [Data Supplement]   

DongFang Wu, Hong Yang, YanFeng Zhao, Chakradhari Sharan, J. Shawn Goodwin, Lichun Zhou, Yang Guo, and ZhongMao Guo

2-Aminopurine Inhibits Lipid Accumulation Induced by Apolipoprotein E-Deficient Lipoprotein in Macrophages: Potential Role of Eukaryotic Initiation Factor-2 Phosphorylation in Foam Cell Formation
J Pharmacol Exp Ther 2008 326: 395-405. Published online May 7, 2008; 10.1124/jpet.107.134833 [Abstract] [Full Text] [PDF]  

Bishara Bishara, Hiba Shiekh, Tony Karram, Irit Rubinstein, Zaher S. Azzam, Niroz Abu-Saleh, Samy Nitecki, Joseph Winaver, Aaron Hoffman, and Zaid A. Abassi

Effects of Novel Vasopressin Receptor Antagonists on Renal Function and Cardiac Hypertrophy in Rats with Experimental Congestive Heart Failure
J Pharmacol Exp Ther 2008 326: 414-422. Published online May 8, 2008; 10.1124/jpet.108.137745 [Abstract] [Full Text] [PDF]  

Robert N. Willette, Weike Bao, Sandhya Nerurkar, Tian-li Yue, Chris P. Doe, Gerald Stankus, Gregory H. Turner, Haisong Ju, Heath Thomas, Cindy E. Fishman, Anthony Sulpizio, David J. Behm, Sandra Hoffman, Zuojun Lin, Irina Lozinskaya, Linda N. Casillas, Min Lin, Robert E. Lee Trout, Bartholomew J. Votta, Kevin Thorneloe, Erin S. R. Lashinger, David J. Figueroa, Robert Marquis, and Xiaoping Xu

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2
J Pharmacol Exp Ther 2008 326: 443-452. Published online May 22, 2008; 10.1124/jpet.107.134551 [Abstract] [Full Text] [PDF] [Data Supplement]   

CELLULAR AND MOLECULAR:

Wai-Pui Tse, Christopher H. K. Cheng, Chun-Tao Che, and Zhi-Xiu Lin

Arsenic Trioxide, Arsenic Pentoxide, and Arsenic Iodide Inhibit Human Keratinocyte Proliferation through the Induction of Apoptosis
J Pharmacol Exp Ther 2008 326: 388-394. Published online May 1, 2008; 10.1124/jpet.107.134080 [Abstract] [Full Text] [PDF]  

E. Davenas, A. Rouleau, S. Morisset, and J. M. Arrang

Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H₃ Receptors
J Pharmacol Exp Ther 2008 326: 406-413. Published online May 12, 2008; 10.1124/jpet.107.135368 [Abstract] [Full Text] [PDF]  

Morley D. Hollenberg, Bernard Renaux, Eric Hyun, Steeve Houle, Nathalie Vergnolle, Mahmoud Saifeddine, and Rithwik Ramachandran

Derivatized 2-Furoyl-LIGRLO-amide, a Versatile and Selective Probe for Proteinase-Activated Receptor 2: Binding and Visualization
J Pharmacol Exp Ther 2008 326: 453-462. Published online May 13, 2008; 10.1124/jpet.108.136432 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Shuqing Lü, Jianmin Yang, Xianmin Song, Shenglan Gong, Hong Zhou, Lieping Guo, Ningxia Song, Xiaochen Bao, Pingping Chen, and Jianmin Wang

Point Mutation of the Proteasome β5 Subunit Gene Is an Important Mechanism of Bortezomib Resistance in Bortezomib-Selected Variants of Jurkat T Cell Lymphoblastic Lymphoma/Leukemia Line
J Pharmacol Exp Ther 2008 326: 423-431. Published online May 23, 2008; 10.1124/jpet.108.138131 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kevin S. Thorneloe, Anthony C. Sulpizio, Zuojun Lin, David J. Figueroa, Angela K. Clouse, Gerald P. McCafferty, Tim P. Chendrimada, Erin S. R. Lashinger, Earl Gordon, Louise Evans, Blake A. Misajet, Douglas J. DeMarini, Josephine H. Nation, Linda N. Casillas, Robert W. Marquis, Bartholomew J. Votta, Steven A. Sheardown, Xiaoping Xu, David P. Brooks, Nicholas J. Laping, and Timothy D. Westfall

N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
J Pharmacol Exp Ther 2008 326: 432-442. Published online May 22, 2008; 10.1124/jpet.108.139295 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yujiro Hayashi, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, Toru Nakamura, Hiroshi Eguchi, Eiji Miyoshi, Norio Hayashi, and Sunao Kawano

Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats
J Pharmacol Exp Ther 2008 326: 523-531. Published online April 30, 2008; 10.1124/jpet.108.137083 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Tsuyoshi Tajima, Takahisa Murata, Kosuke Aritake, Yoshihiro Urade, Hiroyuki Hirai, Masataka Nakamura, Hiroshi Ozaki, and Masatoshi Hori

Lipopolysaccharide Induces Macrophage Migration via Prostaglandin D₂ and Prostaglandin E₂
J Pharmacol Exp Ther 2008 326: 493-501. Published online May 20, 2008; 10.1124/jpet.108.137992 [Abstract] [Full Text] [PDF]  

Ulla Jalonen, Erja-Leena Paukkeri, and Eeva Moilanen

Compounds That Increase or Mimic Cyclic Adenosine Monophosphate Enhance Tristetraprolin Degradation in Lipopolysaccharide-Treated Murine J774 Macrophages
J Pharmacol Exp Ther 2008 326: 514-522. Published online May 9, 2008; 10.1124/jpet.107.133702 [Abstract] [Full Text] [PDF]  

Justin C. Earp, Debra C. DuBois, Diana S. Molano, Nancy A. Pyszczynski, Craig E. Keller, Richard R. Almon, and William J. Jusko

Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis I: Mechanistic Disease Progression Model for the Time Course of Collagen-Induced Arthritis in Lewis Rats
J Pharmacol Exp Ther 2008 326: 532-545. Published online April 30, 2008; 10.1124/jpet.108.137372 [Abstract] [Full Text] [PDF]  

Justin C. Earp, Debra C. DuBois, Diana S. Molano, Nancy A. Pyszczynski, Richard R. Almon, and William J. Jusko

Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis II: Mechanistic Pharmacodynamic Model for Dexamethasone Effects in Lewis Rats with Collagen-Induced Arthritis
J Pharmacol Exp Ther 2008 326: 546-554. Published online April 30, 2008; 10.1124/jpet.108.137414 [Abstract] [Full Text] [PDF]  

Anshu Marathe, Mark C. Peterson, and Donald E. Mager

Integrated Cellular Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma Patients
J Pharmacol Exp Ther 2008 326: 555-562. Published online May 6, 2008; 10.1124/jpet.108.137703 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

Anbrin Masood, Ahmed Nadeem, S. Jamal Mustafa, and James M. O'Donnell

Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice
J Pharmacol Exp Ther 2008 326: 369-379. Published online May 2, 2008; 10.1124/jpet.108.137208 [Abstract] [Full Text] [PDF]  

Fan Jia, Dev Chandra, Gregg E. Homanics, and Neil L. Harrison

Ethanol Modulates Synaptic and Extrasynaptic GABA_A Receptors in the Thalamus
J Pharmacol Exp Ther 2008 326: 475-482. Published online May 13, 2008; 10.1124/jpet.108.139303 [Abstract] [Full Text] [PDF]  

Lisa L. Merritt, B. R. Martin, C. Walters, A. H. Lichtman, and M. Imad Damaj

The Endogenous Cannabinoid System Modulates Nicotine Reward and Dependence
J Pharmacol Exp Ther 2008 326: 483-492. Published online May 1, 2008; 10.1124/jpet.108.138321 [Abstract] [Full Text] [PDF]  

Jere E. Meredith, Jr., Lorin A. Thompson, Jeremy H. Toyn, Lawrence Marcin, Donna M. Barten, Jovita Marcinkeviciene, Lisa Kopcho, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joe Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley A. Lentz, James E. Grace, Jr., Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard E. Olson, John E. Macor, and Charles F. Albright

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice
J Pharmacol Exp Ther 2008 326: 502-513. Published online May 22, 2008; 10.1124/jpet.108.138974 [Abstract] [Full Text] [PDF]  

Linda P. Dwoskin, Thomas E. Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R. Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, Agripina G. Deaciuc, J. Michael McIntosh, Peter A. Crooks, and Michael T. Bardo

N,N'-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-Evoked Dopamine Release and Hyperactivity
J Pharmacol Exp Ther 2008 326: 563-576. Published online May 6, 2008; 10.1124/jpet.108.136630 [Abstract] [Full Text] [PDF]  

Akio Satow, Shunsuke Maehara, Satoko Ise, Hirohiko Hikichi, Miyuki Fukushima, Gentaroh Suzuki, Toshifumi Kimura, Takeshi Tanak, Satoru Ito, Hiroshi Kawamoto, and Hisashi Ohta

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]
J Pharmacol Exp Ther 2008 326: 577-586. Published online May 16, 2008; 10.1124/jpet.108.138107 [Abstract] [Full Text] [PDF] [Data Supplement]   

Vishakantha Murthy, Thomas J. Martin, Susy Kim, Huw M. L. Davies, and Steven R. Childers

In Vivo Characterization of a Novel Phenylisothiocyanate Tropane Analog at Monoamine Transporters in Rat Brain
J Pharmacol Exp Ther 2008 326: 587-595. Published online May 20, 2008; 10.1124/jpet.108.138842 [Abstract] [Full Text] [PDF]  

Hugh E. Criswell, Zhen Ming, M. Katherine Kelm, and George R. Breese

Brain Regional Differences in the Effect of Ethanol on GABA Release from Presynaptic Terminals
J Pharmacol Exp Ther 2008 326: 596-603. Published online May 23, 2008; 10.1124/jpet.107.135418 [Abstract] [Full Text] [PDF]  

Maia Terashvili, Leon F. Tseng, Hsiang-en Wu, Jayashree Narayanan, Lucas M. Hart, John R. Falck, Phillip F. Pratt, and David R. Harder

Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of β-Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray
J Pharmacol Exp Ther 2008 326: 614-622. Published online May 20, 2008; 10.1124/jpet.108.136739 [Abstract] [Full Text] [PDF]  

Simona Colleoni, Anders A. Jensen, Elisa Landucci, Elena Fumagalli, Paola Conti, Andrea Pinto, Marco De Amici, Domenico E. Pellegrini-Giampietro, Carlo De Micheli, Tiziana Mennini, and Marco Gobbi

Neuroprotective Effects of the Novel Glutamate Transporter Inhibitor (–)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic Acid, Which Preferentially Inhibits Reverse Transport (Glutamate Release) Compared with Glutamate Reuptake
J Pharmacol Exp Ther 2008 326: 646-656. Published online May 1, 2008; 10.1124/jpet.107.135251 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Dina Schneider, Maria A. Manzan, Robert B. Crawford, Weimin Chen, and Norbert E. Kaminski

2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Impairment of B Cell Differentiation Involves Dysregulation of Paired Box 5 (Pax5) Isoform, Pax5a
J Pharmacol Exp Ther 2008 326: 463-474. Published online May 15, 2008; 10.1124/jpet.108.139857 [Abstract] [Full Text] [PDF]  

Zhengyu Cao, Joju George, William H. Gerwick, Daniel G. Baden, Jon D. Rainier, and Thomas F. Murray

Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons
J Pharmacol Exp Ther 2008 326: 604-613. Published online April 30, 2008; 10.1124/jpet.108.138230 [Abstract] [Full Text] [PDF]  

Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams, and B. Kevin Park

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
J Pharmacol Exp Ther 2008 326: 657-671. Published online May 1, 2008; 10.1124/jpet.107.135483 [Abstract] [Full Text] [PDF]  

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