JPET -- Table of Contents (325 [2])

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May 2008; 325 (2)   [Index by Author] [Cover Caption]

       PERSPECTIVES IN PHARMACOLOGY

       BEHAVIORAL PHARMACOLOGY

       CARDIOVASCULAR

       CELLULAR AND MOLECULAR

       CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

       GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

       INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

       METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

       NEUROPHARMACOLOGY

       TOXICOLOGY

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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PERSPECTIVES IN PHARMACOLOGY:

Xingrong Liu, Cuiping Chen, and Bill J. Smith: Progress in Brain Penetration Evaluation in Drug Discovery and Development
J Pharmacol Exp Ther 2008 325: 349-356. Published online January 18, 2008; 10.1124/jpet.107.130294 [Abstract] [Full Text] [PDF]

BEHAVIORAL PHARMACOLOGY:

Sara Jane Ward, Timothy W. Lefever, Cavario Jackson, Ronald J. Tallarida, and Ellen A. Walker: Effects of a Cannabinoid₁ Receptor Antagonist and Serotonin_2C Receptor Agonist Alone and in Combination on Motivation for Palatable Food: A Dose-Addition Analysis Study in Mice
J Pharmacol Exp Ther 2008 325: 567-576. Published online February 6, 2008; 10.1124/jpet.107.131771 [Abstract] [Full Text] [PDF]

Gregory T. Collins, Diane M. Calinski, Amy Hauck Newman, Peter Grundt, and James H. Woods: Food Restriction Alters N'-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-Mediated Effects
J Pharmacol Exp Ther 2008 325: 691-697. Published online February 27, 2008; 10.1124/jpet.107.133181 [Abstract] [Full Text] [PDF]

CARDIOVASCULAR:

Sonia Martinez-Revelles, Francesc Jiménez-Altayó, Laura Caracuel, Fernando J. Pérez-Asensio, Anna M. Planas, and Elisabet Vila: Endothelial Dysfunction in Rat Mesenteric Resistance Artery after Transient Middle Cerebral Artery Occlusion
J Pharmacol Exp Ther 2008 325: 363-369. Published online February 7, 2008; 10.1124/jpet.107.134619 [Abstract] [Full Text] [PDF]

Paulus Wohlfart, Hui Xu, Alexandra Endlich, Alice Habermeier, Ellen I. Closs, Thomas Hübschle, Christian Mang, Hartmut Strobel, Teri Suzuki, Hartmut Kleinert, Ulrich Förstermann, Hartmut Ruetten, and Huige Li: Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
J Pharmacol Exp Ther 2008 325: 370-379. Published online February 5, 2008; 10.1124/jpet.107.128009 [Abstract] [Full Text] [PDF]

Carmen Garnacho, Rajwinder Dhami, Eric Simone, Thomas Dziubla, John Leferovich, Edward H. Schuchman, Vladimir Muzykantov, and Silvia Muro: Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers
J Pharmacol Exp Ther 2008 325: 400-408. Published online February 20, 2008; 10.1124/jpet.107.133298 [Abstract] [Full Text] [PDF] [Data Supplement]

Amina Arab, Klaus Kuemmerer, Jin Wang, Christoph Bode, and Christoph Hehrlein: Oxygenated Perfluorochemicals Improve Cell Survival during Reoxygenation by Pacifying Mitochondrial Activity
J Pharmacol Exp Ther 2008 325: 417-424. Published online February 27, 2008; 10.1124/jpet.107.133710 [Abstract] [Full Text] [PDF]

Tian-Li Yue, Sandhya S. Nerurkar, Weike Bao, Beat M. Jucker, Lea Sarov-Blat, Klaudia Steplewski, Eliot H. Ohlstein, and Robert N. Willette: In Vivo Activation of Peroxisome Proliferator-Activated Receptor- ${delta}$ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats
J Pharmacol Exp Ther 2008 325: 466-474. Published online February 20, 2008; 10.1124/jpet.107.135327 [Abstract] [Full Text] [PDF] [Data Supplement]

Alexander R. Mackie, Lioubov I. Brueggemann, Kyle K. Henderson, Aaron J. Shiels, Leanne L. Cribbs, Karie E. Scrogin, and Kenneth L. Byron: Vascular KCNQ Potassium Channels as Novel Targets for the Control of Mesenteric Artery Constriction by Vasopressin, Based on Studies in Single Cells, Pressurized Arteries, and in Vivo Measurements of Mesenteric Vascular Resistance
J Pharmacol Exp Ther 2008 325: 475-483. Published online February 13, 2008; 10.1124/jpet.107.135764 [Abstract] [Full Text] [PDF] [Data Supplement]

Ismayil Ahmet, Melissa Krawczyk, Weizhong Zhu, Anthony Yiu-Ho Woo, Christopher Morrell, Suresh Poosala, Riu-ping Xiao, Edward G. Lakatta, and Mark I. Talan: Cardioprotective and Survival Benefits of Long-Term Combined Therapy with β₂ Adrenoreceptor (AR) Agonist and β₁ AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction
J Pharmacol Exp Ther 2008 325: 491-499. Published online February 20, 2008; 10.1124/jpet.107.135335 [Abstract] [Full Text] [PDF] [Data Supplement]

Jian-Bing Shen and Achilles J. Pappano: An Estrogen Metabolite, 2-Methoxyestradiol, Disrupts Cardiac Microtubules and Unmasks Muscarinic Inhibition of Calcium Current
J Pharmacol Exp Ther 2008 325: 507-512. Published online February 14, 2008; 10.1124/jpet.107.134932 [Abstract] [Full Text] [PDF]

CELLULAR AND MOLECULAR:

Mark A. Hallman, Shougang Zhuang, and Rick G. Schnellmann: Regulation of Dedifferentiation and Redifferentiation in Renal Proximal Tubular Cells by the Epidermal Growth Factor Receptor
J Pharmacol Exp Ther 2008 325: 520-528. Published online February 12, 2008; 10.1124/jpet.107.134031 [Abstract] [Full Text] [PDF]

N. D. Sonawane, Olga Zegarra-Moran, Wan Namkung, Luis J. V. Galietta, and A. S. Verkman: ${alpha}$ -Aminoazaheterocyclic-Methylglyoxal Adducts Do Not Inhibit Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Activity
J Pharmacol Exp Ther 2008 325: 529-535. Published online February 13, 2008; 10.1124/jpet.107.132357 [Abstract] [Full Text] [PDF] [Data Supplement]

Dennis Verzijl, Stefania Storelli, Danny J. Scholten, Leontien Bosch, Todd A. Reinhart, Daniel N. Streblow, Cornelis P. Tensen, Carlos P. Fitzsimons, Guido J. R. Zaman, James E. Pease, Iwan J. P. de Esch, Martine J. Smit, and Rob Leurs: Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors
J Pharmacol Exp Ther 2008 325: 544-555. Published online February 12, 2008; 10.1124/jpet.107.134783 [Abstract] [Full Text] [PDF]

Ingrid P. Fricks, Savitri Maddileti, Rhonda L. Carter, Eduardo R. Lazarowski, Robert A. Nicholas, Kenneth A. Jacobson, and T. Kendall Harden: UDP Is a Competitive Antagonist at the Human P2Y₁₄ Receptor
J Pharmacol Exp Ther 2008 325: 588-594. Published online February 5, 2008; 10.1124/jpet.108.136309 [Abstract] [Full Text] [PDF]

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Olivia Fromigué, Zahia Hamidouche, and Pierre J. Marie: Statin-Induced Inhibition of 3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase Sensitizes Human Osteosarcoma Cells to Anticancer Drugs
J Pharmacol Exp Ther 2008 325: 595-600. Published online February 5, 2008; 10.1124/jpet.108.136127 [Abstract] [Full Text] [PDF]

Ling-hua Meng, Zhaojing Meng, Ze-hong Miao, Timothy D. Veenstra, and Yves Pommier: Cytokeratin-RNA Cross-Linking Mediated by the Antitumor Aminoflavone, 5-Amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
J Pharmacol Exp Ther 2008 325: 674-680. Published online February 20, 2008; 10.1124/jpet.108.137802 [Abstract] [Full Text] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Atsuyasu Sato, Yuma Hoshino, Tomijiro Hara, Shigeo Muro, Hajime Nakamura, Michiaki Mishima, and Junji Yodoi: Thioredoxin-1 Ameliorates Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice
J Pharmacol Exp Ther 2008 325: 380-388. Published online February 6, 2008; 10.1124/jpet.107.134007 [Abstract] [Full Text] [PDF] [Data Supplement]

N. N. Raveendran, K. Silver, L. C. Freeman, D. Narvaez, K. Weng, S. Ganta, and J. D. Lillich: Drug-Induced Alterations to Gene and Protein Expression in Intestinal Epithelial Cell 6 Cells Suggest a Role for Calpains in the Gastrointestinal Toxicity of Nonsteroidal Anti-Inflammatory Agents
J Pharmacol Exp Ther 2008 325: 389-399. Published online February 15, 2008; 10.1124/jpet.107.127720 [Abstract] [Full Text] [PDF] [Data Supplement]

Ming Song, Zhenyuan Song, Shirish Barve, Jingwen Zhang, Theresa Chen, Marcia Liu, Gavin E. Arteel, George J. Brewer, and Craig J. McClain: Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis
J Pharmacol Exp Ther 2008 325: 409-416. Published online February 25, 2008; 10.1124/jpet.107.131227 [Abstract] [Full Text] [PDF] [Erratum]

Kyle A. Rasbach and Rick G. Schnellmann: Isoflavones Promote Mitochondrial Biogenesis
J Pharmacol Exp Ther 2008 325: 536-543. Published online February 11, 2008; 10.1124/jpet.107.134882 [Abstract] [Full Text] [PDF]

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Patsy Clark, Steven E. Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Hugo Poirier, Jason Burch, Yongxin Han, Laurent Audoly, Alex G. Therien, and Daigen Xu: MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis
J Pharmacol Exp Ther 2008 325: 425-434. Published online February 20, 2008; 10.1124/jpet.107.134510 [Abstract] [Full Text] [PDF]

Koh-ichi Yuhki, Fumitaka Ushikubi, Hiroaki Naraba, Akinori Ueno, Hirotsugu Kato, Fumiaki Kojima, Shuh Narumiya, Yukihiko Sugimoto, Misao Matsushita, and Sachiko Oh-ishi: Prostaglandin I₂ Plays a Key Role in Zymosan-Induced Mouse Pleurisy
J Pharmacol Exp Ther 2008 325: 601-609. Published online February 6, 2008; 10.1124/jpet.107.134494 [Abstract] [Full Text] [PDF]

Maki Goto, Satohiro Masuda, Tetsuya Kiuchi, Yasuhiro Ogura, Fumitaka Oike, Koichi Tanaka, Shinji Uemoto, and Ken-ichi Inui: Relation between mRNA Expression Level of Multidrug Resistance 1/ABCB1 in Blood Cells and Required Level of Tacrolimus in Pediatric Living-Donor Liver Transplantation
J Pharmacol Exp Ther 2008 325: 610-616. Published online February 5, 2008; 10.1124/jpet.107.135665 [Abstract] [Full Text] [PDF]

Pranav Patel, Chantal Cossette, Jaganmohan R. Anumolu, Sylvie Gravel, Alain Lesimple, Orval A. Mamer, Joshua Rokach, and William S. Powell: Structural Requirements for Activation of the 5-Oxo-6E,8Z, 11Z,14Z-eicosatetraenoic Acid (5-Oxo-ETE) Receptor: Identification of a Mead Acid Metabolite with Potent Agonist Activity
J Pharmacol Exp Ther 2008 325: 698-707. Published online February 21, 2008; 10.1124/jpet.107.134908 [Abstract] [Full Text] [PDF]

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Jason M. Gow, Laura M. Hodges, Leslie W. Chinn, and Deanna L. Kroetz: Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms
J Pharmacol Exp Ther 2008 325: 435-442. Published online February 20, 2008; 10.1124/jpet.107.135194 [Abstract] [Full Text] [PDF]

Yuji Tanaka, Lauren M. Aleksunes, Ronnie L. Yeager, Maxwell A. Gyamfi, Noriko Esterly, Grace L. Guo, and Curtis D. Klaassen: NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet
J Pharmacol Exp Ther 2008 325: 655-664. Published online February 15, 2008; 10.1124/jpet.107.135822 [Abstract] [Full Text] [PDF] [Data Supplement]

NEUROPHARMACOLOGY:

Nobuko Matsumura, Kazue Kikuchi-Utsumi, and Toshio Nakaki: Activities of 7-Nitroindazole and 1-(2-(Trifluoromethylphenyl)-imidazole Independent of Neuronal Nitric-Oxide Synthase Inhibition
J Pharmacol Exp Ther 2008 325: 357-362. Published online February 12, 2008; 10.1124/jpet.107.135160 [Abstract] [Full Text] [PDF]

Xavier Rovira, David Roche, Juan Serra, Julie Kniazeff, Jean-Philippe Pin, and Jesús Giraldo: Modeling the Binding and Function of Metabotropic Glutamate Receptors
J Pharmacol Exp Ther 2008 325: 443-456. Published online February 20, 2008; 10.1124/jpet.107.133967 [Abstract] [Full Text] [PDF] [Data Supplement]

Daniel J. Foster, Anne M. Heacock, Richard F. Keep, and Stephen K. Fisher: Activation of Muscarinic Cholinergic Receptors on Human SH-SY5Y Neuroblastoma Cells Enhances Both the Influx and Efflux of K⁺ under Conditions of Hypo-Osmolarity
J Pharmacol Exp Ther 2008 325: 457-465. Published online February 15, 2008; 10.1124/jpet.107.135475 [Abstract] [Full Text] [PDF]

Robert B. Raffa and Dennis J. Stone, Jr.: Unexceptional Seizure Potential of Tramadol or Its Enantiomers or Metabolites in Mice
J Pharmacol Exp Ther 2008 325: 500-506. Published online February 21, 2008; 10.1124/jpet.108.137273 [Abstract] [Full Text] [PDF]

Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda, and William A. Banks: Delivery of Galanin-Like Peptide to the Brain: Targeting with Intranasal Delivery and Cyclodextrins
J Pharmacol Exp Ther 2008 325: 513-519. Published online February 12, 2008; 10.1124/jpet.107.132381 [Abstract] [Full Text] [PDF]

Mary M. Torregrossa and Peter W. Kalivas: Neurotensin in the Ventral Pallidum Increases Extracellular ${gamma}$ -Aminobutyric Acid and Differentially Affects Cue- and Cocaine-Primed Reinstatement
J Pharmacol Exp Ther 2008 325: 556-566. Published online February 5, 2008; 10.1124/jpet.107.130310 [Abstract] [Full Text] [PDF]

William J. Thomsen, Andrew J. Grottick, Frederique Menzaghi, Hazel Reyes-Saldana, Stephen Espitia, Diane Yuskin, Kevin Whelan, Michael Martin, Michael Morgan, Weichao Chen, Hussien Al-Shamma, Brian Smith, Derek Chalmers, and Dominic Behan: Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine_2C Agonist: in Vitro and in Vivo Pharmacological Characterization
J Pharmacol Exp Ther 2008 325: 577-587. Published online February 5, 2008; 10.1124/jpet.107.133348 [Abstract] [Full Text] [PDF] [Data Supplement]

Zhihua Xie and Gregory M. Miller: β-Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain
J Pharmacol Exp Ther 2008 325: 617-628. Published online January 8, 2008; 10.1124/jpet.107.134247 [Abstract] [Full Text] [PDF]

Zhihua Xie, Susan V. Westmoreland, and Gregory M. Miller: Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes
J Pharmacol Exp Ther 2008 325: 629-640. Published online February 29, 2008; 10.1124/jpet.107.135079 [Abstract] [Full Text] [PDF]

Khalid Benamar, Ellen B. Geller, and Martin W. Adler: First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain
J Pharmacol Exp Ther 2008 325: 641-645. Published online February 15, 2008; 10.1124/jpet.107.135053 [Abstract] [Full Text] [PDF] [Erratum]

Kathryn O'Leary, Neeraja Parameswaran, J. Michael McIntosh, and Maryka Quik: Cotinine Selectively Activates a Subpopulation of ${alpha}$ 3/ ${alpha}$ 6β2 Nicotinic Receptors in Monkey Striatum
J Pharmacol Exp Ther 2008 325: 646-654. Published online February 27, 2008; 10.1124/jpet.108.136838 [Abstract] [Full Text] [PDF]

Tracy A. Brooks, Nicole Nametz, Rachael Charles, and Thomas P. Davis: Diclofenac Attenuates the Regional Effect of ${lambda}$ -Carrageenan on Blood-Brain Barrier Function and Cytoarchitecture
J Pharmacol Exp Ther 2008 325: 665-673. Published online February 27, 2008; 10.1124/jpet.107.135632 [Abstract] [Full Text] [PDF]

C. J. Schmidt, D. S. Chapin, J. Cianfrogna, M. L. Corman, M. Hajos, J. F. Harms, W. E. Hoffman, L. A. Lebel, S. A. McCarthy, F. R. Nelson, C. Proulx-LaFrance, M. J. Majchrzak, A. D. Ramirez, K. Schmidt, P. A. Seymour, J. A. Siuciak, F. D. Tingley, III, R. D. Williams, P. R. Verhoest, and F. S. Menniti: Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
J Pharmacol Exp Ther 2008 325: 681-690. Published online February 20, 2008; 10.1124/jpet.107.132910 [Abstract] [Full Text] [PDF]

TOXICOLOGY:

L. Harivardhan Reddy, Pierre-Emmanuel Marque, Catherine Dubernet, Sinda-Lepêtre Mouelhi, Didier Desmaële, and Patrick Couvreur: Preclinical Toxicology (Subacute and Acute) and Efficacy of a New Squalenoyl Gemcitabine Anticancer Nanomedicine
J Pharmacol Exp Ther 2008 325: 484-490. Published online February 7, 2008; 10.1124/jpet.107.133751 [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Cover Caption:

About the cover: The mGlu model. The VFT domain is represented by OO, OC, and CC dimer states, free (upper row), singly bound (middle row), or doubly bound (lower row). See the article by Rovira et al. on page 443 of this issue.