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March 2008; 324 (3)   [Index by Author] [Cover Caption]

       PERSPECTIVES IN PHARMACOLOGY

       CARDIOVASCULAR

       CELLULAR AND MOLECULAR

       CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

       ENDOCRINE AND DIABETES

       GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

       INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

       METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

       NEUROPHARMACOLOGY

       TOXICOLOGY

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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PERSPECTIVES IN PHARMACOLOGY:

Anthony A. Sauve: NAD⁺ and Vitamin B₃: From Metabolism to Therapies
J Pharmacol Exp Ther 2008 324: 883-893. Published online December 28, 2007; 10.1124/jpet.107.120758 [Abstract] [Full Text] [PDF]

CARDIOVASCULAR:

Jo G. R. De Mey, Remco Megens, and Gregorio E. Fazzi: Functional Antagonism between Endogenous Neuropeptide Y and Calcitonin Gene-Related Peptide in Mesenteric Resistance Arteries
J Pharmacol Exp Ther 2008 324: 930-937. Published online November 30, 2007; 10.1124/jpet.107.133660 [Abstract] [Full Text] [PDF] [Data Supplement]

Wenqi Yang, Venugopal Raju Tuniki, Siddam Anjaiah, J. R. Falck, Cecilia J. Hillard, and William B. Campbell: Characterization of Epoxyeicosatrienoic Acid Binding Site in U937 Membranes Using a Novel Radiolabeled Agonist, 20-¹²⁵I-14,15-Epoxyeicosa-8(Z)-Enoic Acid
J Pharmacol Exp Ther 2008 324: 1019-1027. Published online January 2, 2008; 10.1124/jpet.107.129577 [Abstract] [Full Text] [PDF] [Data Supplement]

Jennifer L. Strande, Anna Hsu, Jidong Su, Xiangping Fu, Garrett J. Gross, and John E. Baker: Inhibiting Protease-Activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling
J Pharmacol Exp Ther 2008 324: 1045-1054. Published online November 30, 2007; 10.1124/jpet.107.133595 [Abstract] [Full Text] [PDF]

Tilo Görnemann, Harald Hübner, Peter Gmeiner, Reinhard Horowski, Klaus Peter Latté, Miroslav Flieger, and Heinz H. Pertz: Characterization of the Molecular Fragment That Is Responsible for Agonism of Pergolide at Serotonin 5-Hydroxytryptamine_2B and 5-Hydroxytryptamine_2A Receptors
J Pharmacol Exp Ther 2008 324: 1136-1145. Published online December 20, 2007; 10.1124/jpet.107.133165 [Abstract] [Full Text] [PDF]

Mounir Errami, Cristi L. Galindo, Amina T. Tassa, John M. DiMaio, Joseph A. Hill, and Harold R. Garner: Doxycycline Attenuates Isoproterenol- and Transverse Aortic Banding-Induced Cardiac Hypertrophy in Mice
J Pharmacol Exp Ther 2008 324: 1196-1203. Published online December 18, 2007; 10.1124/jpet.107.133975 [Abstract] [Full Text] [PDF]

Tamara J. van Steeg, Jan Freijer, Meindert Danhof, and Elizabeth C. M. de Lange: Mechanism-Based Pharmacodynamic Modeling of S(–)-Atenolol: Estimation of in Vivo Affinity for the β₁-Adrenoceptor with an Agonist-Antagonist Interaction Model
J Pharmacol Exp Ther 2008 324: 1234-1242. Published online December 27, 2007; 10.1124/jpet.107.131680 [Abstract] [Full Text] [PDF]

CELLULAR AND MOLECULAR:

Narasimharao Bhagavathula, Kamalakar C. Nerusu, Andrew Hanosh, Muhammad N. Aslam, Thomas B. Sundberg, Anthony W. Opipari, Jr., Kent Johnson, Sewon Kang, Gary D. Glick, and James Varani: 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
J Pharmacol Exp Ther 2008 324: 938-947. Published online November 30, 2007; 10.1124/jpet.107.130955 [Abstract] [Full Text] [PDF]

Ivan Zahradník, Igor Minarovic, and Alexandra Zahradníková: Inhibition of the Cardiac L-Type Calcium Channel Current by Antidepressant Drugs
J Pharmacol Exp Ther 2008 324: 977-984. Published online November 29, 2007; 10.1124/jpet.107.132456 [Abstract] [Full Text] [PDF]

Amel Dudakovic, Andrew J. Wiemer, Kimberly M. Lamb, Laura A. Vonnahme, Sara E. Dietz, and Raymond J. Hohl: Inhibition of Geranylgeranyl Diphosphate Synthase Induces Apoptosis through Multiple Mechanisms and Displays Synergy with Inhibition of Other Isoprenoid Biosynthetic Enzymes
J Pharmacol Exp Ther 2008 324: 1028-1036. Published online December 14, 2007; 10.1124/jpet.107.132217 [Abstract] [Full Text] [PDF]

Brian F. King and Andrea Townsend-Nicholson: Involvement of P2Y₁ and P2Y₁₁ Purinoceptors in Parasympathetic Inhibition of Colonic Smooth Muscle
J Pharmacol Exp Ther 2008 324: 1055-1063. Published online November 29, 2007; 10.1124/jpet.107.131169 [Abstract] [Full Text] [PDF]

Kelly A. Berg, John Dunlop, Teresa Sanchez, Michelle Silva, and William P. Clarke: A Conservative, Single-Amino Acid Substitution in the Second Cytoplasmic Domain of the Human Serotonin_2C Receptor Alters Both Ligand-Dependent and -Independent Receptor Signaling
J Pharmacol Exp Ther 2008 324: 1084-1092. Published online December 7, 2007; 10.1124/jpet.107.131524 [Abstract] [Full Text] [PDF]

María J. Muñoz-Alonso, Laura González-Santiago, Natasha Zarich, Teresa Martínez, Enrique Alvarez, José María Rojas, and Alberto Muñoz: Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH₂-Terminal Kinase Activation in Human Melanoma Cells
J Pharmacol Exp Ther 2008 324: 1093-1101. Published online December 18, 2007; 10.1124/jpet.107.132662 [Abstract] [Full Text] [PDF]

Robert C. Bucelli, Eugene A. Gonsiorek, Woo-Yang Kim, Donald Bruun, Richard A. Rabin, Dennis Higgins, and Pamela J. Lein: Statins Decrease Expression of the Proinflammatory Neuropeptides Calcitonin Gene-Related Peptide and Substance P in Sensory Neurons
J Pharmacol Exp Ther 2008 324: 1172-1180. Published online December 13, 2007; 10.1124/jpet.107.132795 [Abstract] [Full Text] [PDF]

Kun Don Yi, Zu Yun Cai, Douglas F. Covey, and James W. Simpkins: Estrogen Receptor-Independent Neuroprotection via Protein Phosphatase Preservation and Attenuation of Persistent Extracellular Signal-Regulated Kinase 1/2 Activation
J Pharmacol Exp Ther 2008 324: 1188-1195. Published online December 18, 2007; 10.1124/jpet.107.132308 [Abstract] [Full Text] [PDF]

Sumaya N. Hamadmad and Raymond J. Hohl: Erythropoietin Stimulates Cancer Cell Migration and Activates RhoA Protein through a Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase-Dependent Mechanism
J Pharmacol Exp Ther 2008 324: 1227-1233. Published online December 13, 2007; 10.1124/jpet.107.129643 [Abstract] [Full Text] [PDF]

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ayaz Mehar, Patricia Macanas-Pirard, Atsushi Mizokami, Yutaka Takahashi, Georges E. N. Kass, and Helen M. Coley: The Effects of Cyclooxygenase-2 Expression in Prostate Cancer Cells: Modulation of Response to Cytotoxic Agents
J Pharmacol Exp Ther 2008 324: 1181-1187. Published online December 18, 2007; 10.1124/jpet.107.131383 [Abstract] [Full Text] [PDF]

ENDOCRINE AND DIABETES:

Rosemary J. Santulli, William A. Kinney, Shyamali Ghosh, Bart L. DeCorte, Li Liu, Robert W. A. Tuman, Zhao Zhou, Norman Huebert, Sven E. Bursell, Alan C. Clermont, Maria B. Grant, Lynn C. Shaw, Shaker A. Mousa, Robert A. Galemmo, Jr., Dana L. Johnson, Bruce E. Maryanoff, and Bruce P. Damiano: Studies with an Orally Bioavailable ${alpha}$ _V Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats
J Pharmacol Exp Ther 2008 324: 894-901. Published online December 14, 2007; 10.1124/jpet.107.131656 [Abstract] [Full Text] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

W. I. Hagens, L. Beljaars, D.A. Mann, M. C. Wright, B. Julien, S. Lotersztajn, C. Reker-Smit, and K. Poelstra: Cellular Targeting of the Apoptosis-Inducing Compound Gliotoxin to Fibrotic Rat Livers
J Pharmacol Exp Ther 2008 324: 902-910. Published online December 12, 2007; 10.1124/jpet.107.132290 [Abstract] [Full Text] [PDF]

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Christine Linard, Olivier Grémy, and Marc Benderitter: Reduction of Peroxisome Proliferation-Activated Receptor ${gamma}$ Expression by ${gamma}$ -Irradiation as a Mechanism Contributing to Inflammatory Response in Rat Colon: Modulation by the 5-Aminosalicylic Acid Agonist
J Pharmacol Exp Ther 2008 324: 911-920. Published online December 12, 2007; 10.1124/jpet.107.129122 [Abstract] [Full Text] [PDF]

Satyanarayana Medicherla, Mary F. Fitzgerald, Dianne Spicer, Paul Woodman, Jing Y. Ma, Ann M. Kapoun, Sarvajit Chakravarty, Sundeep Dugar, Andrew A. Protter, and Linda S. Higgins: p38 ${alpha}$ -Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
J Pharmacol Exp Ther 2008 324: 921-929. Published online December 4, 2007; 10.1124/jpet.107.127092 [Abstract] [Full Text] [PDF]

Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Torsten Loop, Klaus K. Geiger, Heike L. Pahl, and Benedikt H.J. Pannen: Thionamides Inhibit the Transcription Factor Nuclear Factor- ${kappa}$ B by Suppression of Rac1 and Inhibitor of ${kappa}$ B Kinase ${alpha}$
J Pharmacol Exp Ther 2008 324: 1037-1044. Published online November 30, 2007; 10.1124/jpet.107.132407 [Abstract] [Full Text] [PDF]

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Ana M. Pajor, Kathleen M. Randolph, Sandy A. Kerner, and Chari D. Smith: Inhibitor Binding in the Human Renal Low- and High-Affinity Na⁺/Glucose Cotransporters
J Pharmacol Exp Ther 2008 324: 985-991. Published online December 6, 2007; 10.1124/jpet.107.129825 [Abstract] [Full Text] [PDF]

Eric C.K. Siu and Rachel F. Tyndale: Selegiline Is a Mechanism-Based Inactivator of CYP2A6 Inhibiting Nicotine Metabolism in Humans and Mice
J Pharmacol Exp Ther 2008 324: 992-999. Published online December 7, 2007; 10.1124/jpet.107.133900 [Abstract] [Full Text] [PDF]

Michel Demeule, Anthony Régina, Christian Ché, Julie Poirier, Tran Nguyen, Reinhard Gabathuler, Jean-Paul Castaigne, and Richard Béliveau: Identification and Design of Peptides as a New Drug Delivery System for the Brain
J Pharmacol Exp Ther 2008 324: 1064-1072. Published online December 21, 2007; 10.1124/jpet.107.131318 [Abstract] [Full Text] [PDF]

Albert L. Shroads, Xu Guo, Vaishali Dixit, Hui-Ping Liu, Margaret O. James, and Peter W. Stacpoole: Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity
J Pharmacol Exp Ther 2008 324: 1163-1171. Published online December 20, 2007; 10.1124/jpet.107.134593 [Abstract] [Full Text] [PDF]

E. Yang, R. R. Almon, D. C. DuBois, W. J. Jusko, and I. P. Androulakis: Extracting Global System Dynamics of Corticosteroid Genomic Effects in Rat Liver
J Pharmacol Exp Ther 2008 324: 1243-1254. Published online December 17, 2007; 10.1124/jpet.107.133074 [Abstract] [Full Text] [PDF]

NEUROPHARMACOLOGY:

Lothar Lindemann, Claas Aiko Meyer, Karine Jeanneau, Amyaouch Bradaia, Laurence Ozmen, Horst Bluethmann, Bernhard Bettler, Joseph G. Wettstein, Edilio Borroni, Jean-Luc Moreau, and Marius C. Hoener: Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
J Pharmacol Exp Ther 2008 324: 948-956. Published online December 14, 2007; 10.1124/jpet.107.132647 [Abstract] [Full Text] [PDF] [Data Supplement]

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming-Chih Crouthamel, Xiao-Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason Kahana, Joan Ellis, Lixia Jin, Thomas Steele, Shawn Stachel, Craig Coburn, and Adam J. Simon: In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased ${alpha}$ -Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
J Pharmacol Exp Ther 2008 324: 957-969. Published online December 21, 2007; 10.1124/jpet.107.130039 [Abstract] [Full Text] [PDF] [Data Supplement]

Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen, and Hui-Lin Pan: Increased C-Fiber Nociceptive Input Potentiates Inhibitory Glycinergic Transmission in the Spinal Dorsal Horn
J Pharmacol Exp Ther 2008 324: 1000-1010. Published online December 13, 2007; 10.1124/jpet.107.133470 [Abstract] [Full Text] [PDF]

Xiang-Qun Hu and Robert W. Peoples: Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine_3A Receptor
J Pharmacol Exp Ther 2008 324: 1011-1018. Published online December 19, 2007; 10.1124/jpet.107.131011 [Abstract] [Full Text] [PDF]

Yulin Wang, Yong Chen, Wei Xu, David Y.W. Lee, Zhongze Ma, Scott M. Rawls, Alan Cowan, and Lee-Yuan Liu-Chen: 2-Methoxymethyl-Salvinorin B Is a Potent ${kappa}$ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A
J Pharmacol Exp Ther 2008 324: 1073-1083. Published online December 18, 2007; 10.1124/jpet.107.132142 [Abstract] [Full Text] [PDF]

Joseph P. Tizzano, D. Sloan Stribling, Diego Perez-Tilve, Alison Strack, Andrea Frassetto, Richard Z. Chen, Tung M. Fong, Lauren Shearman, Philip A. Krieter, Matthias H. Tschöp, Phil Skolnick, and Anthony S. Basile: The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity
J Pharmacol Exp Ther 2008 324: 1111-1126. Published online December 18, 2007; 10.1124/jpet.107.133132 [Abstract] [Full Text] [PDF]

Fan Jia, Minerva Yue, Dev Chandra, Gregg E. Homanics, Peter A. Goldstein, and Neil L. Harrison: Isoflurane Is a Potent Modulator of Extrasynaptic GABA_A Receptors in the Thalamus
J Pharmacol Exp Ther 2008 324: 1127-1135. Published online December 19, 2007; 10.1124/jpet.107.134569 [Abstract] [Full Text] [PDF]

Steve McGaraughty, Katharine L. Chu, Marc J. C. Scanio, Michael E. Kort, Connie R. Faltynek, and Michael F. Jarvis: A Selective Na_v1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
J Pharmacol Exp Ther 2008 324: 1204-1211. Published online December 18, 2007; 10.1124/jpet.107.134148 [Abstract] [Full Text] [PDF]

Mark J. Millan, Florence Loiseau, Anne Dekeyne, Alain Gobert, Gunnar Flik, Thomas I. Cremers, Jean-Michel Rivet, Dorothée Sicard, Rodolphe Billiras, and Mauricette Brocco: S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D₃ versus D₂ Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects
J Pharmacol Exp Ther 2008 324: 1212-1226. Published online December 20, 2007; 10.1124/jpet.107.134536 [Abstract] [Full Text] [PDF]

TOXICOLOGY:

Pablo R. Castello, Derek A. Drechsel, Brian J. Day, and Manisha Patel: Inhibition of Mitochondrial Hydrogen Peroxide Production by Lipophilic Metalloporphyrins
J Pharmacol Exp Ther 2008 324: 970-976. Published online December 6, 2007; 10.1124/jpet.107.132134 [Abstract] [Full Text] [PDF]

Iain A. Murray and Gary H. Perdew: Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation
J Pharmacol Exp Ther 2008 324: 1102-1110. Published online November 30, 2007; 10.1124/jpet.107.132241 [Abstract] [Full Text] [PDF]

Bin Li, Ellen G. Duysen, Michaela Carlson, and Oksana Lockridge: The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency
J Pharmacol Exp Ther 2008 324: 1146-1154. Published online December 4, 2007; 10.1124/jpet.107.133330 [Abstract] [Full Text] [PDF]

Grazyna Nowak, Ginger L. Clifton, and Diana Bakajsova: Succinate Ameliorates Energy Deficits and Prevents Dysfunction of Complex I in Injured Renal Proximal Tubular Cells
J Pharmacol Exp Ther 2008 324: 1155-1162. Published online November 30, 2007; 10.1124/jpet.107.130872 [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Cover Caption:

About the cover: The Trace amine-associated receptor 1 (TAAR1) is expressed in multiple areas of the mouse brain, including the ventral tegmental area. Dopaminergic neurons in this region show an increased firing frequency in TAAR1 knockout compared to wild-type mice. See the article by Lindemann et al. on page 948 of this issue.