PERSPECTIVES IN PHARMACOLOGY:

Diana Donnelly-Roberts, Steve McGaraughty, Char-Chang Shieh, Prisca Honore, and Michael F. Jarvis

Painful Purinergic Receptors
J Pharmacol Exp Ther 2008 324: 409-415. Published online November 27, 2007; 10.1124/jpet.106.105890 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Chengke Tang, Taliah Mittler, Dawn C. Duke, Yun Zhu, Anthony P. Pawlak, and Mark O. West

Dose- and Rate-Dependent Effects of Cocaine on Striatal Firing Related to Licking
J Pharmacol Exp Ther 2008 324: 701-713. Published online November 8, 2007; 10.1124/jpet.107.129734 [Abstract] [Full Text] [PDF]  

Emily M. Jutkiewicz, Michelle G. Baladi, John E. Folk, Kenner C. Rice, and James H. Woods

The -Opioid Receptor Agonist SNC80 [(+)-4-[(R)--[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] Synergistically Enhances the Locomotor-Activating Effects of Some Psychomotor Stimulants, but Not Direct Dopamine Agonists, in Rats
J Pharmacol Exp Ther 2008 324: 714-724. Published online November 6, 2007; 10.1124/jpet.107.123844 [Abstract] [Full Text] [PDF]  

Bradford D. Fischer, Eric I. Zimmerman, Mitchell J. Picker, and Linda A. Dykstra

Morphine in Combination with Metabotropic Glutamate Receptor Antagonists on Schedule-Controlled Responding and Thermal Nociception
J Pharmacol Exp Ther 2008 324: 732-739. Published online November 2, 2007; 10.1124/jpet.107.131417 [Abstract] [Full Text] [PDF]  

Jun-Xu Li, Kenner C. Rice, and Charles P. France

Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane in Rhesus Monkeys
J Pharmacol Exp Ther 2008 324: 827-833. Published online November 9, 2007; 10.1124/jpet.107.130625 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Antonio E. Lacerda, Yuri A. Kuryshev, Yuan Chen, Muthukrishnan Renganathan, Heather Eng, Sanjay J. Danthi, James W. Kramer, Tianen Yang, and Arthur M. Brown

Alfuzosin Delays Cardiac Repolarization by a Novel Mechanism
J Pharmacol Exp Ther 2008 324: 427-433. Published online November 6, 2007; 10.1124/jpet.107.128405 [Abstract] [Full Text] [PDF]  

Patricia W. Bedard, Valerie Clerin, Natalia Sushkova, Boris Tchernychev, Thomas Antrilli, Christine Resmini, James C. Keith, Jr., James K. Hennan, Neelu Kaila, Silvano DeBernardo, Kristin Janz, Qin Wang, David L. Crandall, Robert G. Schaub, Gray D. Shaw, and Laura L. Carter

Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis
J Pharmacol Exp Ther 2008 324: 497-506. Published online November 16, 2007; 10.1124/jpet.107.128124 [Abstract] [Full Text] [PDF]  

Angela Tesse, Ghassan Al-Massarani, Rosemary Wangensteen, Sebastien Reitenbach, M. Carmen Martínez, and Ramaroson Andriantsitohaina

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor- Agonist, Prevents Microparticle-Induced Vascular Hyporeactivity through the Regulation of Proinflammatory Proteins
J Pharmacol Exp Ther 2008 324: 539-547. Published online November 26, 2007; 10.1124/jpet.107.130278 [Abstract] [Full Text] [PDF]  

Cort S. Madsen, Evan Janovitz, Rongan Zhang, Van Nguyen-Tran, Carol S. Ryan, Xiaohong Yin, Hossain Monshizadegan, Ming Chang, Celia D'Arienzo, Susan Scheer, Robert Setters, Debra Search, Xing Chen, Shaobin Zhuang, Lori Kunselman, Andrew Peters, Thomas Harrity, Atsu Apedo, Christine Huang, Carolyn A. Cuff, Mark C. Kowala, Michael A. Blanar, Chong-qing Sun, Jeffrey A. Robl, and Philip D. Stein

The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins
J Pharmacol Exp Ther 2008 324: 576-586. Published online November 6, 2007; 10.1124/jpet.107.131615 [Abstract] [Full Text] [PDF]  

Jeong Hun Kim, Jin Hyoung Kim, Young Suk Yu, Kyu Hyung Park, Hye Jin Kang, Ho-Young Lee, and Kyu-Won Kim

Antiangiogenic Effect of Deguelin on Choroidal Neovascularization
J Pharmacol Exp Ther 2008 324: 643-647. Published online October 29, 2007; 10.1124/jpet.107.132720 [Abstract] [Full Text] [PDF]  

Yu-Jung Chen and John Quilley

Fenofibrate Treatment of Diabetic Rats Reduces Nitrosative Stress, Renal Cyclooxygenase-2 Expression, and Enhanced Renal Prostaglandin Release
J Pharmacol Exp Ther 2008 324: 658-663. Published online November 9, 2007; 10.1124/jpet.107.129197 [Abstract] [Full Text] [PDF]  

Regiane Miranda-Ferreira, Ricardo de Pascual, Antonio M. G. de Diego, Afonso Caricati-Neto, Luis Gandía, Aron Jurkiewicz, and Antonio G. García

Single-Vesicle Catecholamine Release Has Greater Quantal Content and Faster Kinetics in Chromaffin Cells from Hypertensive, as Compared with Normotensive, Rats
J Pharmacol Exp Ther 2008 324: 685-693. Published online October 25, 2007; 10.1124/jpet.107.128819 [Abstract] [Full Text] [PDF]  

Monica Gomaraschi, Laura Calabresi, Giuseppe Rossoni, Stefania Iametti, Guido Franceschini, John A. Stonik, and Alan T. Remaley

Anti-Inflammatory and Cardioprotective Activities of Synthetic High-Density Lipoprotein Containing Apolipoprotein A-I Mimetic Peptides
J Pharmacol Exp Ther 2008 324: 776-783. Published online November 27, 2007; 10.1124/jpet.107.129411 [Abstract] [Full Text] [PDF]  

Dorota Zolkowska, Michael H. Baumann, and Richard B. Rothman

Chronic Fenfluramine Administration Increases Plasma Serotonin (5-Hydroxytryptamine) to Nontoxic Levels
J Pharmacol Exp Ther 2008 324: 791-797. Published online November 21, 2007; 10.1124/jpet.107.132654 [Abstract] [Full Text] [PDF]  

Woei-Cherng Shyu, Shinn-Zong Lin, Pao-Sheng Yen, Ching-Yuan Su, Der-Cherng Chen, Hsiao-Jung Wang, and Hung Li

Stromal Cell-Derived Factor-1 Promotes Neuroprotection, Angiogenesis, and Mobilization/Homing of Bone Marrow-Derived Cells in Stroke Rats
J Pharmacol Exp Ther 2008 324: 834-849. Published online November 20, 2007; 10.1124/jpet.107.127746 [Abstract] [Full Text] [PDF]  

George D. Webb, Lay Har Lim, Vernon M. S. Oh, Soh Bee Yeo, Yoke Ping Cheong, Muhammed Yusuf Ali, Reida El Oakley, Chuen Neng Lee, Poo Sing Wong, Michael G. Caleb, Manuel Salto-Tellez, Madhav Bhatia, Edwin S. Y. Chan, Elizabeth A. Taylor, and Philip K. Moore

Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery
J Pharmacol Exp Ther 2008 324: 876-882. Published online November 20, 2007; 10.1124/jpet.107.133538 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Jeffrey F. Waring, Yi Yang, Christine H. Healan-Greenberg, Andrew L. Adler, Robert Dickinson, Teresa McNally, Xiaojun Wang, Moshe Weitzberg, Xiangdong Xu, Andrew Lisowski, Scott E. Warder, Yu Gui Gu, Bradley A. Zinker, Eric A. Blomme, and Heidi S. Camp

Gene Expression Analysis in Rats Treated with Experimental Acetyl-Coenzyme A Carboxylase Inhibitors Suggests Interactions with the Peroxisome Proliferator-Activated Receptor Pathway
J Pharmacol Exp Ther 2008 324: 507-516. Published online November 19, 2007; 10.1124/jpet.107.126938 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Vivienna Ong, Natalia L. M. Liem, Michael A. Schmid, Nicole M. Verrills, Rachael A. Papa, Glenn M. Marshall, Karen L. MacKenzie, Maria Kavallaris, and Richard B. Lock

A Role for Altered Microtubule Polymer Levels in Vincristine Resistance of Childhood Acute Lymphoblastic Leukemia Xenografts
J Pharmacol Exp Ther 2008 324: 434-442. Published online November 6, 2007; 10.1124/jpet.107.128926 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ting Wang, Xiaochao Ma, Kristopher W. Krausz, Jeffrey R. Idle, and Frank J. Gonzalez

Role of Pregnane X Receptor in Control of All-Trans Retinoic Acid (ATRA) Metabolism and Its Potential Contribution to ATRA Resistance
J Pharmacol Exp Ther 2008 324: 674-684. Published online October 25, 2007; 10.1124/jpet.107.131045 [Abstract] [Full Text] [PDF]  

Aniruddha C. Amrite and Uday B. Kompella

Celecoxib Inhibits Proliferation of Retinal Pigment Epithelial and Choroid-Retinal Endothelial Cells by a Cyclooxygenase-2-Independent Mechanism
J Pharmacol Exp Ther 2008 324: 749-758. Published online November 21, 2007; 10.1124/jpet.107.128918 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Koji Nobe, Taigi Yamazaki, Toshio Kumai, Masako Okazaki, Shinichi Iwai, Terumasa Hashimoto, Shinichi Kobayashi, Katsuji Oguchi, and Kazuo Honda

Alterations of Glucose-Dependent and -Independent Bladder Smooth Muscle Contraction in Spontaneously Hypertensive and Hyperlipidemic Rat
J Pharmacol Exp Ther 2008 324: 631-642. Published online November 1, 2007; 10.1124/jpet.107.131334 [Abstract] [Full Text] [PDF]  

Akbar Jafarnejad, S. Zahra Bathaie, Manouchehr Nakhjavani, and Mohammad Z. Hassan

Investigation of the Mechanisms Involved in the High-Dose and Long-Term Acetyl Salicylic Acid Therapy of Type I Diabetic Rats
J Pharmacol Exp Ther 2008 324: 850-857. Published online November 13, 2007; 10.1124/jpet.107.130914 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kumi Ishida, Shinji Takai, Mitsuyuki Murano, Takashi Nishikawa, Takuya Inoue, Naoko Murano, Nao Inoue, Denan Jin, Eiji Umegaki, Kazuhide Higuchi, and Mizuo Miyazaki

Role of Chymase-Dependent Matrix Metalloproteinase-9 Activation in Mice with Dextran Sodium Sulfate-Induced Colitis
J Pharmacol Exp Ther 2008 324: 422-426. Published online November 16, 2007; 10.1124/jpet.107.131946 [Abstract] [Full Text] [PDF]  

Nieves Gonzalez, Simon J. Hocart, Sergio Portal-Nuñez, Samuel A. Mantey, Tomoo Nakagawa, Enrique Zudaire, David H. Coy, and Robert T. Jensen

Molecular Basis for Agonist Selectivity and Activation of the Orphan Bombesin Receptor Subtype 3 Receptor
J Pharmacol Exp Ther 2008 324: 463-474. Published online November 15, 2007; 10.1124/jpet.107.132332 [Abstract] [Full Text] [PDF]  

Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E. Alvarez, Scott L. Friedman, Vicente Arroyo, and Wladimiro Jiménez

Regression of Fibrosis after Chronic Stimulation of Cannabinoid CB2 Receptor in Cirrhotic Rats
J Pharmacol Exp Ther 2008 324: 475-483. Published online November 20, 2007; 10.1124/jpet.107.131896 [Abstract] [Full Text] [PDF]  

Mónica Porras, Maria Teresa Martín, Evangelina Terán, Marisabel Mourelle, and Patri Vergara

The Nitric Oxide Donor LA-419 [S-(6-Nitro-oxi-hexahydro-furo[3,2-b]furan-3-1-il)thioacetate] Prevents Intestinal Dysmotility, Bacterial Translocation, and Inflammation in a Rat Model of Enteritis
J Pharmacol Exp Ther 2008 324: 740-748. Published online October 24, 2007; 10.1124/jpet.107.129189 [Abstract] [Full Text] [PDF]  

Takami Saji, Ryota Kikuchi, Hiroyuki Kusuhara, Insook Kim, Frank J. Gonzalez, and Yuichi Sugiyama

Transcriptional Regulation of Human and Mouse Organic Anion Transporter 1 by Hepatocyte Nuclear Factor 1 /β
J Pharmacol Exp Ther 2008 324: 784-790. Published online November 20, 2007; 10.1124/jpet.107.128249 [Abstract] [Full Text] [PDF]  

Prapapimon Pariwat, Sureeporn Homvisasevongsa, Chatchai Muanprasat, and Varanuj Chatsudthipong

A Natural Plant-Derived Dihydroisosteviol Prevents Cholera Toxin-Induced Intestinal Fluid Secretion
J Pharmacol Exp Ther 2008 324: 798-805. Published online November 21, 2007; 10.1124/jpet.107.129288 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Maxwell Afari Gyamfi, Lin He, Samuel William French, Ivan Damjanov, and Yu-Jui Yvonne Wan

Hepatocyte Retinoid X Receptor -Dependent Regulation of Lipid Homeostasis and Inflammatory Cytokine Expression Contributes to Alcohol-Induced Liver Injury
J Pharmacol Exp Ther 2008 324: 443-453. Published online November 1, 2007; 10.1124/jpet.107.132258 [Abstract] [Full Text] [PDF]  

María Marta Escribese, Elisa Conde, David Sáenz-Morales, Peter L. Hordijk, and María Laura García-Bermejo

Mononuclear Cell Extravasation in an Inflammatory Response Is Abrogated by All-Trans-Retinoic Acid through Inhibiting the Acquisition of an Appropriate Migratory Phenotype
J Pharmacol Exp Ther 2008 324: 454-462. Published online October 31, 2007; 10.1124/jpet.107.127225 [Abstract] [Full Text] [PDF]  

Emanuela Masini, Lucia Giannini, Silvia Nistri, Lorenzo Cinci, Rosanna Mastroianni, Wei Xu, Suzy A. A. Comhair, Dechun Li, Salvatore Cuzzocrea, George M. Matuschak, and Daniela Salvemini

Ceramide: a Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation
J Pharmacol Exp Ther 2008 324: 548-557. Published online November 27, 2007; 10.1124/jpet.107.131565 [Abstract] [Full Text] [PDF]  

Sham Mohd Saleh, Tracy S. Mann, Terence Peters, Richard J. Betts, and Peter J. Henry

Influence of Dexamethasone on Protease-Activated Receptor 2-Mediated Responses in the Airways
J Pharmacol Exp Ther 2008 324: 622-630. Published online November 14, 2007; 10.1124/jpet.107.132753 [Abstract] [Full Text] [PDF]  

Sergey Ryzhov, Rinat Zaynagetdinov, Anna E. Goldstein, Sergey V. Novitskiy, Michael R. Blackburn, Italo Biaggioni, and Igor Feoktistov

Effect of A_2B Adenosine Receptor Gene Ablation on Adenosine-Dependent Regulation of Proinflammatory Cytokines
J Pharmacol Exp Ther 2008 324: 694-700. Published online October 26, 2007; 10.1124/jpet.107.131540 [Abstract] [Full Text] [PDF]  

Mario Mellado, Ana Martín de Ana, Lucio Gómez, Carlos Martínez-A, and José Miguel Rodríguez-Frade

Chemokine Receptor 2 Blockade Prevents Asthma in a Cynomolgus Monkey Model
J Pharmacol Exp Ther 2008 324: 769-775. Published online November 20, 2007; 10.1124/jpet.107.128538 [Abstract] [Full Text] [PDF]  

Linda M. Ayer, Sylvia M. Wilson, Suzanne L. Traves, David Proud, and Mark A. Giembycz

4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) Is a Selective, Pseudo-Irreversible Orthosteric Antagonist at the Prostacyclin (IP)-Receptor Expressed by Human Airway Epithelial Cells: IP-Receptor-Mediated Inhibition of CXCL9 and CXCL10 Release
J Pharmacol Exp Ther 2008 324: 815-826. Published online October 25, 2007; 10.1124/jpet.107.129312 [Abstract] [Full Text] [PDF] [Data Supplement]   

Outi Sareila, Mari Hämäläinen, Erkki Nissinen, Hannu Kankaanranta, and Eeva Moilanen

Orazipone Inhibits Activation of Inflammatory Transcription Factors Nuclear Factor-B and Signal Transducer and Activator of Transcription 1 and Decreases Inducible Nitric-Oxide Synthase Expression and Nitric Oxide Production in Response to Inflammatory Stimuli
J Pharmacol Exp Ther 2008 324: 858-866. Published online November 26, 2007; 10.1124/jpet.107.129114 [Abstract] [Full Text] [PDF]  

Anne M. O'Rourke, Eric Y. Wang, Andrew Miller, Erika M. Podar, Kelly Scheyhing, Li Huang, Christina Kessler, Hongfeng Gao, Huong-Thu Ton-Nu, Mary T. MacDonald, David S. Jones, and Matthew D. Linnik

Anti-Inflammatory Effects of LJP 1586 [Z-3-Fluoro-2-(4-methoxybenzyl)allylamine Hydrochloride], an Amine-Based Inhibitor of Semicarbazide-Sensitive Amine Oxidase Activity
J Pharmacol Exp Ther 2008 324: 867-875. Published online November 9, 2007; 10.1124/jpet.107.131672 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Gerard Minuesa, Sergi Purcet, Itziar Erkizia, Míriam Molina-Arcas, Margarita Bofill, Nuria Izquierdo-Useros, F. Javier Casado, Bonaventura Clotet, Marçal Pastor-Anglada, and Javier Martinez-Picado

Expression and Functionality of Anti-Human Immunodeficiency Virus and Anticancer Drug Uptake Transporters in Immune Cells
J Pharmacol Exp Ther 2008 324: 558-567. Published online November 27, 2007; 10.1124/jpet.107.131482 [Abstract] [Full Text] [PDF]  

Yazen Alnouti and Curtis D. Klaassen

Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice
J Pharmacol Exp Ther 2008 324: 612-621. Published online November 9, 2007; 10.1124/jpet.107.129650 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Christopher A. Salvatore, James C. Hershey, Halea A. Corcoran, John F. Fay, Victor K. Johnston, Eric L. Moore, Scott D. Mosser, Christopher S. Burgey, Daniel V. Paone, Anthony W. Shaw, Samuel L. Graham, Joseph P. Vacca, Theresa M. Williams, Kenneth S. Koblan, and Stefanie A. Kane

Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine
J Pharmacol Exp Ther 2008 324: 416-421. Published online November 26, 2007; 10.1124/jpet.107.130344 [Abstract] [Full Text] [PDF] [Data Supplement]   

L. Leanne Lash, James M. Sanders, Nobuyuki Akiyama, Muneo Shoji, Pekka Postila, Olli T. Pentikäinen, Makoto Sasaki, Ryuichi Sakai, and Geoffrey T. Swanson

Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors
J Pharmacol Exp Ther 2008 324: 484-496. Published online November 21, 2007; 10.1124/jpet.107.129890 [Abstract] [Full Text] [PDF]  

Mark J. Millan, Clotilde Mannoury la Cour, Francesca Novi, Roberto Maggio, Valérie Audinot, Adrian Newman-Tancredi, Didier Cussac, Valérie Pasteau, Jean-A. Boutin, Thierry Dubuffet, and Gilbert Lavielle

S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], A Preferential Dopamine D₃ versus D₂ Receptor Antagonist and Potential Antipsychotic Agent: I. Receptor-Binding Profile and Functional Actions at G-Protein-Coupled Receptors
J Pharmacol Exp Ther 2008 324: 587-599. Published online November 16, 2007; 10.1124/jpet.107.126706 [Abstract] [Full Text] [PDF]  

Mark J. Millan, Per Svenningsson, Charles R. Ashby, Jr., Michael Hill, Martin Egeland, Anne Dekeyne, Mauricette Brocco, Benjamin Di Cara, Françoise Lejeune, Nitza Thomasson, Carmen Munoz, Elisabeth Mocaër, Alan Crossman, Laetitia Cistarelli, Sylvie Girardon, Loretta Iob, Sylvie Veiga, and Alain Gobert

S33138 [N-[4-[2-[(3aS,9bR)-8-Cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a Preferential Dopamine D₃ versus D₂ Receptor Antagonist and Potential Antipsychotic Agent. II. A Neurochemical, Electrophysiological and Behavioral Characterization in Vivo
J Pharmacol Exp Ther 2008 324: 600-611. Published online November 16, 2007; 10.1124/jpet.107.132563 [Abstract] [Full Text] [PDF]  

Tooba A. Cheema and Stephen K. Fisher

Cholesterol Regulates Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Receptor Activation
J Pharmacol Exp Ther 2008 324: 648-657. Published online November 8, 2007; 10.1124/jpet.107.131110 [Abstract] [Full Text] [PDF]  

Diana L. McKinney, Michael P. Cassidy, Lauren M. Collier, Billy R. Martin, Jenny L. Wiley, Dana E. Selley, and Laura J. Sim-Selley

Dose-Related Differences in the Regional Pattern of Cannabinoid Receptor Adaptation and in Vivo Tolerance Development to ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 2008 324: 664-673. Published online October 29, 2007; 10.1124/jpet.107.130328 [Abstract] [Full Text] [PDF]  

K. N. Hascup, E. R. Hascup, F. Pomerleau, P. Huettl, and G. A. Gerhardt

Second-by-Second Measures of L-Glutamate in the Prefrontal Cortex and Striatum of Freely Moving Mice
J Pharmacol Exp Ther 2008 324: 725-731. Published online November 16, 2007; 10.1124/jpet.107.131698 [Abstract] [Full Text] [PDF]  

Tobias Johansson, Per-Anders Frändberg, Fred Nyberg, and Pierre Le Grevès

Molecular Mechanisms for Nanomolar Concentrations of Neurosteroids at NR1/NR2B Receptors
J Pharmacol Exp Ther 2008 324: 759-768. Published online November 15, 2007; 10.1124/jpet.107.130518 [Abstract] [Full Text] [PDF]  

Elizabeth W. Tringham, Jonathan R. B. Dupere, C. Elizabeth Payne, and Maria M. Usowicz

Protease Treatment of Cerebellar Purkinje Cells Renders -Agatoxin IVA-Sensitive Ca²⁺ Channels Insensitive to Inhibition by -Conotoxin GVIA
J Pharmacol Exp Ther 2008 324: 806-814. Published online November 1, 2007; 10.1124/jpet.107.130641 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Christina J. Herden, Nicole E. Pardo, Ravindra K. Hajela, Yukun Yuan, and William D. Atchison

Differential Effects of Methylmercury on -Aminobutyric Acid Type A Receptor Currents in Rat Cerebellar Granule and Cerebral Cortical Neurons in Culture
J Pharmacol Exp Ther 2008 324: 517-528. Published online October 31, 2007; 10.1124/jpet.107.123976 [Abstract] [Full Text] [PDF]  

Toshiyuki Arai, Mitsuru Nonogawa, Keisuke Makino, Nobuyuki Endo, Hiroko Mori, Takashi Miyoshi, Kouhei Yamashita, Masataka Sasada, Masahiro Kakuyama, and Kazuhiko Fukuda

The Radical Scavenger Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one) Reacts with a Pterin Derivative and Produces a Cytotoxic Substance That Induces Intracellular Reactive Oxygen Species Generation and Cell Death
J Pharmacol Exp Ther 2008 324: 529-538. Published online November 20, 2007; 10.1124/jpet.107.131391 [Abstract] [Full Text] [PDF]  

Andrea Caroline Knapp, Liliane Todesco, Konstantin Beier, Luigi Terracciano, Hans Sägesser, Jürg Reichen, and Stephan Krähenbühl

Toxicity of Valproic Acid in Mice with Decreased Plasma and Tissue Carnitine Stores
J Pharmacol Exp Ther 2008 324: 568-575. Published online November 6, 2007; 10.1124/jpet.107.131185 [Abstract] [Full Text] [PDF]  

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